Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

By S. Yousefi, J. Gold, Nicola Andina, James J. Lee, Ann M. Kelly, E. Kozlowski, Inès Schmid, A. Straumann, J. Reichenbach, G. Gleich and 1 more. Nature Medicine, 2008

958 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7d0fc8d2c0d7aca2804b586ac5ba5638f21d70c5

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In Immunology

Citations in the corpus

Mitochondrial DNA in inflammation and immunity (2020, positive): “It is now also appreciated that other cell types, including lymphocytes and eosinophils, can secrete mtDNA-containing webs which act to prime type I interferon responses in peripheral blood mononuclear cells [158,159].”
Extracellular DNA traps promote thrombosis (2010, background): “Although we suspect that extracellular DNA came from neutrophils, we cannot exclude participation of other leukocytes as well (12, 13).”
Eosinophils: changing perspectives in health and disease (2012, background): “More recently, in vivo studies of the interaction of eosinophils with bacteria documented the catapultlike release of structures resembling neutrophil extracellular traps (NETs) from eosinophils, and this was associated with protection from the lethal sequelae of caecal ligation 65 .”
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010, methodology): “Mast cells, eosinophils, and plant cells also release DNA, which suggests that this may be a common strategy in immunity (von Köckritz-Blickwede et al., 2008; Yousefi et al., 2008; Wen et al., 2009).”
The neutrophil in vascular inflammation (2011, background): “In separate studies, eosinophils and neutrophils were found to catapult their DNA out of the cell into the extracellular space, but the DNA source was non-nuclear and, instead, the DNA originated from the mitochondria 82, 83 .”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “eosinophils can release the so-called neutrophil extracellular traps (NETs), that is, microbicidal structures composed of nuclear chromatin, histones and granular antimicrobial proteins.(157,158) Upon the administration of granulocyte– macrophage colony-stimulating factor (GMCSF) or short-term stimu”
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality (2011, positive): “context broader than cell death because they observed that even viable eosinophils and neutrophils release extracellular traps.(19,63) In these studies, eosinophils and neutrophils were pretreated with the pro-inflammatory cytokines IL-5þ IFNg or with GM-CSFþC5a, respectively.”
Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “cells [4] and eosinophils [5], release web-like extracellular traps”