The neutrophil in vascular inflammation

By M. Phillipson, P. Kubes. Nature Medicine, 2011

760 citations recorded by the source corpus.

Here we focus on how neutrophils have a key regulatory role in vascular inflammation. Recent studies using advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these processes may be disrupted in systemic infections, with a particular emphasis on mouse models of sepsis. Neutrophils are often immobilized in the lungs and liver during systemic infections, and this immobilization may be a mechanism through which bacteria can evade the innate immune response or allow neutrophils to form neutrophil extracellular traps that trap and kill bacteria in blood. The platelet is also an important player in sepsis, and we describe how it collaborates with neutrophils in the formation of neutrophil extracellular traps.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/cb595605210e5ec858626579d470a58f34a54b87

Citations in the corpus

• Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. (2013, neutral): “Neutrophils are the predominant circulating granulocyte in humans and comprise 50%–75% of circulating leukocytes (32).”
• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “known as ‘‘neutrophil extracellular traps’’ (NETS) are also released as an antimicrobial defence mechanism (279,280).”