Extracellular DNA traps promote thrombosis

By T. Fuchs, A. Brill, D. Duerschmied, Daphne Schatzberg, M. Monestier, D. Myers, S. Wrobleski, T. Wakefield, J. Hartwig, D. Wagner. Proceedings of the National Academy of Sciences of the United States of America, 2010

2,446 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/23940373bc0cb8b31171e6a6bfb5af008c059f74

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Arturo Zychlinsky
2. A. Mócsai
3. V. Brinkmann
4. C. Rosales
5. P. Kubes
6. M. Kaplan
7. C. Jenne
8. M. Egeblad

In Hematology

1. M. Egeblad
2. N. Borregaard
3. D. Scadden

In Immunology

1. P. Kubes
2. A. Mócsai
3. C. Rosales
4. Arturo Zychlinsky
5. V. Brinkmann
6. N. Borregaard
7. K. Martinod
8. D. Wagner

Citations in the corpus

• Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Thrombosis is caused by the release of TF, cytokines, and other inflammatory mediators during NETosis occurring as a result of infection, autoimmune disease, and cancer (75, 176).”
• Hypercoagulability of COVID‐19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis (2020, neutral): “Antithrombin (U/dL) 102 (82-122) 11 74 (45-120) 6 (55) 0 (0) 10 (91) 1 (9)”
• Neutrophils, from marrow to microbes. (2010, background): “Along the same lines, NETs were shown to induce thrombosis by stimulating platelets in vitro, and NET components were abundant in thrombi induced in a baboon model (Fuchs et al., 2010).”
• Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice (2018, background): “A growing body of evidence indicates a role for NETs, not just in infections but also in noninfectious inflammatory diseases (13), thrombosis (16, 17), and impaired wound healing in diabetes (18).”
• Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. (2012, background): “Numerous reports have demonstrated roles for NETs in tissue damage and disease pathology in a number of infectious, inflammatory, and autoimmune diseases (Clark et al., 2007; Fuchs et al., 2010; Kessenbrock et al., 2009; Villanueva et al., 2011).”
• Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “Indeed, NETs were shown to be able to trigger platelet activation and thrombus formation in vitro (Fuchs et al., 2010).”
• Neutrophil extracellular traps: Is immunity the second function of chromatin? (2012, background): “There, neutrophils produce NETs that serve as a scaffold for the stimulation of thrombus formation (Fuchs et al., 2010).”
• Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “Furthermore, NETs serve as a platform for the docking and activation of platelets.(42) Direct engagement of microbes by platelets also contributes to platelet stimulation and thrombosis.”
• The Multifaceted Functions of Neutrophils (2013, background): “NETs also induce platelet procoagulant activation, which can lead to significant thrombosis and vascular injury (134).”
• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “In fact, several reports indicate that NETs can influence thrombosis (Fuchs et al., 2010) and vascular inflammation (Kessenbrock et al.”
• Thrombosis: tangled up in NETs. (2014, background): “In this flow model, RBCs bind to NETs but not collagen.(31) Within thrombi formed in vivo, NETs colocalize withVWF.”