Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

By M. Garcia-Barros, F. Paris, C. Cordon-Cardo, D. Lyden, Shahin Rafii, A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick. Science, 2003

1,596 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/7c7936d69a9ac1b3bee033d1b79eb787a3bbb74c

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In Cancer Research

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In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Disrupting tumour blood vessels (2005, background): “In radiotherapy, damage to the tumour vasculature is increasingly recognized as influencing tumour-cell surviva”
Radiation oncology: a century of achievements (2004, background): “Richard Kolesnick and Zvi Fuks demonstrated that by making endothelial cells refractory to radiation without changing the sensitivity of tumour cells, they could alter the radiosensitivity of transplanted tumours to single-dose radiotherap”
Lessons from phase III clinical trials on anti-VEGF therapy for cancer (2006, background): “Similar to chemotherapy, certain doses of ionizing radiation can induce apoptosis in tumor endothelial cells in mice”
Biologically active sphingolipids in cancer pathogenesis and treatment (2004, background): “Also, A-SMase has been implicated in mediating apoptosis induced by radiatio”
Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “density within tumors, and as a consequence of that, also to a reduced IFP [95], via the generation of radicals which damage the DNA and lead to tumor and endothelial cell apoptosis [96,97].”
The anti-angiogenic basis of metronomic chemotherapy (2004, background): “, but there are reports that claim that up to 50% of the endothelial cells in newly forming blood vessels come from CEP”
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. (2004, methodology): “The recent mouse experiments were approved by the Massachusetts General Hospital study by Garcia-Barros et al. (2003) suggested that damage to Subcommittee on Research Animal Care. tumor-associated endothelial cells plays a crucial role in the outcome of radiation therapy.”
The cell biology of lysosomal storage disorders (2004, neutral): “For example,in acid-sphingomyelinase-knockout models,changes in apoptosis at the cell and tissue level have been observed 64,65 .”
A perivascular niche for brain tumor stem cells. (2007, background): “For example, solid tumor xenografts grown in mice with radiation-resistant endothelial cells are much less sensitive to radiation damage than tumors grown in wild-type mice (Garcia-Barros et al., 2003).”
Strategies to improve radiotherapy with targeted drugs (2011, background): “These studies were stimulated by initial reports showing that endothelial damage in tumours, primarily through a membrane-mediated apoptotic response, affected tumour responses to local radiotherap”