Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
By F. Winkler, S. Kozin, Ricky T. Tong, Sung-suk Chae, M. F. Booth, I. Garkavtsev, Lei Xu, D. Hicklin, Dai Fukumura, E. di Tomaso and 2 more. Cancer Cell, 2004
1,344 citations recorded by the source corpus.
Subfields: Cancer Research, Modeling and Simulation, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b034d78980f5b1a84f82a36fd98cb4d452242b41
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Rakesh K. Jain
- J. Joyce
- Dai Fukumura
- Peter Carmeliet
- Lance L. Munn
- B. Larrivée
- C. Viallard
- John D. Martin
In Modeling and Simulation
In Molecular Biology
- Rakesh K. Jain
- J. Joyce
- Dai Fukumura
- Peter Carmeliet
- J. Pollard
- Lance L. Munn
- John D. Martin
- B. Larrivée
Citations in the corpus
- Therapeutic targeting of the tumor microenvironment. (2005, positive): “…nists, and TGF β inhibitors, among others, effectively reduces IFP, resulting in enhanced drug uptake (Lammerts et al., 2002; Pietras et al., 2002; Tong et al., 2004), as exemplified by the combinatorial efficacy of chemotherapy and PDGF inhibitors in reducing tumor growth in preclinical models…”
- Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “…stages of clinical testing that aim to target VEGF/VEGFR signaling pathways: (1) monoclonal antibodies directed against VEGF or its receptor(s) (Winkler et al. 2004; Vredenburgh et al. 2007), (2) small molecule inhibitors of VEGFR-2 tyrosine kinase activity (Batchelor et al. 2007), and (3)…”
- Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. (2007, background): “Another potential mechanism is normalization of the tumor vasculature as proposed by Jain et al.(30-32) Tumor angiogenesis”
- Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. (2005, methodology): “We transplanted human glioma cells (U87 cells; Winkler et al., 2004) in the striatum of nude mice, which were previously transplanted with Tie2-tk transgenic BM-derived lin− cells.”
- Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, methodology): “3) [Tong et al., 2004; Winkler et al., 2004].”