Regulation of E2F1 activity by acetylation

By M. Martínez-Balbás, U. Bauer, S. Nielsen, A. Brehm, Tony Kouzarides. EMBO Journal, 2000

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View Paper: https://www.semanticscholar.org/paper/7c74a50d4eb9d830cc5789994f657a19081ae1ba

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Citations in the corpus

The Rb/E2F pathway: expanding roles and emerging paradigms. (2000, background): “Therefore, recruitment of HDAC to E2F via Rb may inhibit E2F activity by deacetylation of the protein, thereby inhibiting its binding to DNA (Fig.”
Structure of a -TrCP1-Skp1--Catenin Complex (2003, background): “sampling the vicinity of the E2 through random diffusion, transcription factor (Li and Verma, 2002; Martinez-Balbas et al., 2000).”
CBP/p300 in cell growth, transformation, and development. (2000, background): “This group has recently extended this model by showing that E2F1 can be acetylated by P/CAF, a CBP/ p300-associated factor, and to a lessor degree by CBP/ p300 itself (Martinez-Balbas et al. 2000).”
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, neutral): “HDACs have also been implicated in the reversible acetylation of nonhistone proteins, including p53 (Luo et al., 2001; Vaziri et al., 2001), Hsp90 (Kovacs et al., 2005), MyoD (Mal et al., 2001), and E2F1 (Martinez-Balbas et al., 2000).”
p300/CBP and cancer (2004, background): “…(Eckner et al., 1994; Bannister and Kouzarides, 1995; Bannister et al., 1995; Avantaggiati et al., 1997; Lill et al., 1997; Pouponnot et al., 1998; Patel et al., 1999; Ghosh et al., 2000; Martinez-Balbas et al., 2000; Marzio et al., 2000; Pao et al., 2000; Tomita et al., 2000; Chan et al., 2001).”
Histone Deacetylase Inhibitors: Overview and Perspectives (2007, neutral): “Protein Substrates of HDACs (Partial List) Functional Group Protein HDAC Implicated References Structural protein a-Tubulin HDAC6 (19) Chaperone protein Hsp90 HDAC6 (84) DNA binding nuclear receptors Androgen receptor HDAC1 (85) Glucocorticoid receptor HDAC2 (86) Estrogen receptor a ND (87) SHP HDAC”
Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “E2F1 is acetylated by p300/CBP-associated factor (PCAF), which enhances its DNA-binding, transactivation activity, and stability, and transforms E2F1 into an activator of transcription (Martinez-Balbas et al., 2000).”
Anticancer activities of histone deacetylase inhibitors (2006, background): “For example, the gene regulatory activity of transcription factors such as E2F1, p53, STAT1, STAT3 and NF-κB can be modulated through direct acetylation and deacetylation of the factors themselves, and all of these proteins are hyperacetylated in response to HDAC”
Acetylation: a regulatory modification to rival phosphorylation? (2000, background): “Many of these substrates are involved in the regulation of transcription and include p53, E2F1, EKLF, TFIIEβ, TFIIF, TCF, GATA1, HMGI(Y) and ACTR (Gu and Roeder, 1997; Imhof et al., 1997; Boyes et al., 1998; Munshi et al., 1998; Waltzer and Bienz, 1998; Zhang and Bieker et al., 1998; Chen et al., 19”