Structure of a -TrCP1-Skp1--Catenin Complex

By Geng Wu, Guozhou Xu, B. Schulman, P. Jeffrey, J. Harper, N. Pavletich. 2003

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Analyzing Protein Disorder with IUPred2A (2020, background): “At the N-terminus there are multiple overlapping motif sites that correspond to phosphorylation sites, and a phosphodegron motif which regulates the degradation of the protein (Wu et al., 2003).”
Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling (2013, background): “…well as in β-TrCP, another WD40 β-propeller Ub-ligase that interacts with phosphorylated motifs in target proteins) the phosphopeptide-binding site is located on the top surface of the propeller domain (Figure 3—figure supplements 1 and 2) (Orlicky et al., 2003; Wu et al., 2003; Hao et al., 2007).”