The Microbiome and the Respiratory Tract
By Robert P. Dickson, John R. Erb-Downward, F. Martinez, G. Huffnagle. Annual Review of Physiology, 2015
817 citations recorded by the source corpus.
Although the notion that “the normal lung is free from bacteria” remains common in textbooks, it is virtually always stated without citation or argument. The lungs are constantly exposed to diverse communities of microbes from the oropharynx and other sources, and over the past decade, novel culture-independent techniques of microbial identification have revealed that the lungs, previously considered sterile in health, harbor diverse communities of microbes. In this review, we describe the topography and population dynamics of the respiratory tract, both in health and as altered by acute and chronic lung disease. We provide a survey of current techniques of sampling, sequencing, and analysis of respiratory microbiota and review technical challenges and controversies in the field. We review and synthesize what is known about lung microbiota in various diseases and identify key lessons learned across disease states.
Subfields: Emergency Medical Services, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/ecbc6af4a3791ff86dc351f5233b8811b5fa6a0f
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In Molecular Biology
Citations in the corpus
- SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract (2020, neutral): “In contrast, it is well-known that an oral-lung aspiration axis is a key contributor to many lower airways infectious diseases (Dickson et al., 2016; Esther et al., 2019; Gaeckle et al., 2020; Odani et al., 2019; Phillips et al., 2015).”
- Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity (2017, background): “…and Proteobacteria phyla, which included the species from Streptococcus, Veillonella, Prevotella, Pseudomonas, Haemophilus, and Neisseria (Charlson et al., 2011; Morris et al., 2013; Allen et al., 2014; Botero et al., 2014; Bassis et al., 2015; Dickson et al., 2015a,b; Tarabichi et al., 2015).”
- Microbiota in health and diseases (2022, background): “The majority of microbes in lungs belong to Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria families.(111) The lung microbiota is responsible for the state of immune tolerance that protects the host from undesired inflammatory response.”