Protein tyrosine kinase structure and function.

By S. Hubbard, J. Till. Annual Review of Biochemistry, 2000

1,177 citations recorded by the source corpus.

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Citations in the corpus

Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. (2006, background): “Autophosphorylation has been shown to play a crucial role in animal RTK activation (Hubbard and Till 2000) and also occurs in several plant RLKs including FLS2 (Nasrallah 2000; Gomez-Gomez et al.”
The protein tyrosine kinase family of the human genome (2000, background): “Summary Hubbard and Till, 2000; Hunter, 2000; Robertson et al., 2000; Cole et al., 1999; Fischer, 1999; Schenk and Snaar-Jagalska, 1999; Hubbard et al., 1998; Porter and Vaillancourt, 1998; Hunter, 1997; Johnson et al., 1996; Hanks and Hunter, 1995 Non-receptor families Neet and Hunter, 1996 ABL…”
Structure and regulation of Src family kinases (2004, background): “Bound nucleotide phosphates are in part coordinated by the glycine-rich G loop (also termed the P-loop, for phosphate binding) (Taylor et al., 1992; Hubbard and Till, 2000).”
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, background): “Such conserved sites are abundant in the tyrosine kinase domain (32), indicating that this domain is under strong selection pressure to maintain the general IR signal transduction functions.”
Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “Activation of the eceptor protein-tyrosine kinases and the initiation of sigal transduction involve autophosphorylation of tyrosine esidues [40].”
Mechanisms of specificity in protein phosphorylation (2007, background): “Non-receptor Tyr kinases, for example, almost always have well-defined interaction domains, such as Src -homology-2 (SH2), SH3, integrin binding, focal adhesion binding, DNA binding, F-actin binding, pleckstrin homology, or Janus tyrosine kinase (JAK) homology domain”
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. (2003, background): “This domain rearrangement gives rise to the extended configuration, and breaks the tion causes them to become autophosphorylated within the activation loop (Hubbard and Till, 2000).”
RTK and TGF-β signaling pathways genes in the sea urchin genome (2006, background): “a tyrosine kinase activity (RTK) and bind a variety of growth factors while the second comprises the receptors that phosphorylate serine or threonine residues and bind members of the TGFβ family (Hubbard and Till, 2000; Shi and Massague, 2003).”
The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing (2015, background): “All four FGFRs share structural homology with vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), and other tyrosine kinase receptors, which has implications for pharmacologic therapy (2).”
Oncogenic kinase signalling (2001, background): “Crystal structures of the inactive forms of the core cytoplasmic kinase domains of the insulin receptor (InsR), fibroblast growth factor receptor-1 (FGFR1) and Flk1 (vascular endothelial growth factor receptor-2 or VEGFR2) tyrosine kinases have provided a molecular understanding of the tight control”
Lectin Receptor Kinases in Plants (2002, background): “This C-terminal domain is considered as a regulatory region susceptible to interact with signaling proteins (see Schlessinger, 2000, and Hubbard and Till, 2000 for review).”
Plant Receptor-Like Kinase Gene Family: Diversity, Function, and Signaling (2001, background): “These differences in phosphorylation might reflect the differences in the mechanism of receptor activation observed in animal RTKs (13).”