The protein tyrosine kinase family of the human genome

By D. Robinson, Yi-Mi Wu, Su-Fang Lin. Oncogene, 2000

1,178 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/ba0f39054afadd558797965df4ccdea28eae0380

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Z. Du
2. Christine Lovly

In Molecular Biology

1. D. Graham
2. Jordi Bruix1 , 2
3. H. Earp
4. Z. Du
5. A. Keating
6. R. Linger
7. Christine Lovly

In Radiology, Nuclear Medicine and Imaging

1. Jordi Bruix1 , 2
2. J. Llovet
3. Z. Du
4. Christine Lovly

Citations in the corpus

• TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. (2008, background): “The 58 RTKs in the human genome are classified into 20 families by amino acid sequence identity within the kinase domain and structural similarities within their extracellular regions (Robinson et al., 2000).”
• Clinical Pharmacokinetics of Imatinib (2005, background): “[1,2] Deregulation of cellular homolog of the viral oncogene v-kit.”
• EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, background): “Activation of this pathway is dependant upon overexpression of ligands and hypermethylation of promoters of tumor suppressors inducing transcription of genes of the AP-1 family, such as c-Fos and c-Jun involved in proliferation and differentiation [310].”
• EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, background): “Activation of this pathway is dependant upon overexpression of ligands and hypermethylation of promoters of tumor suppressors inducing transcription of genes of the AP-1 family, such as c-Fos and c-Jun involved in proliferation and differentiation [310].”
• Mechanisms of receptor tyrosine kinase activation in cancer (2018, positive): “There are 58 known RTKs in humans [1, 2], and all RTKs share a similar protein structure comprised of an extracellular ligand binding domain, a single transmembrane helix, and an intracellular region that contains a juxtamembrane regulatory region, a tyrosine kinase domain (TKD) and a carboxyl (C-) ”