Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

By A. Kamal, A. Almenar-Queralt, J. LeBlanc, E. A. Roberts, L. Goldstein. Nature, 2001

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APP processing and synaptic function. (2003, positive): “tant physiological functions (Cao and Sudhof, 2001; Kamal et al., 2001), and thus, the consequence of overThe regulatory mechanisms that control A biosynthesis have received much interest, as these are attracexpressing APP may have unanticipated effects on physiological and behavioral measures of le”
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008, neutral): “, 1992) Ab40 (rabbit) Ala-40; Ab1^40 1:1000 Chemicon (Kamal et al., 2001) Ab42 (rabbit) Ala-42; Ab1^42 1:1000 Chemicon (Kamal et al.”
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. (2002, background): “It was recently reported that BACE, presenilin 1, and APP are all transported along axons in membrane vesicles that require APP/kinesin-1 interactions and that vesicle preparations from peripheral nerves can generate A .55 Based on these findings and the fact that these vesicles also carry additiona”
The axonal transport of mitochondria (2005, background): “Several potential motor protein receptors and adaptors have been identified for axonal vesicles, including the membrane or membrane-associated proteins APP (Kamal et al., 2000; Kamal et al., 2001; Gunawardena and Goldstein, 2001) (see Lazarov et al.”