Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

By M. Schaller. Journal of Cell Science, 2010

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The Blood-Testis Barrier and Its Implications for Male Contraception (2012, background): “In contrast to members of the Src family kinases, FAK does not possess a myristoylation site to anchor itself to the plasma membrane, and it also lacks putative Src homology 2 (SH2) and SH3 domains required for proteinprotein interactions, even though FAK has multiple binding partners in epithelia, ”
FAK promotes recruitment of talin to nascent adhesions to control cell motility (2012, background): “FAK E1015A is activated by FN replating but does not rescue adhesion or motility defects of FAK/ MEFs FAK is activated in a cell adhesion–dependent manner as detected by phospho-specific antibodies to the FAK Y397 auto-phosphorylation site upon FN replating (Schaller, 2010).”