Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

By S. Szabo, B. Sullivan, Claudia Stemmann, A. Satoskar, B. Sleckman, Laurie H. Glimcher. Science, 2002

1,206 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/79ffcd158a3c5e604a028fa98edfa6ab0611a260

How researchers see this paper

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In Immunology

1. M. Bevan
2. Rafi Ahmed
3. R. Seder
4. J. Matsuda
5. Anjana Rao
6. Laurie H. Glimcher
7. L. Gapin
8. M. Pipkin

Citations in the corpus

• Immunomodulatory functions of type I interferons (2012, background): “Initial studies found that IL-12 signalling in CD4 + T cells and the subsequent activation of STAT4, which in turn promotes T-bet expression, are crucial events in T helper 1 (T H 1) cell differentiatio”
• Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “However, CpG stimuli did not enhance T-bet expression, unless exogenous IL-12 was also provided (Joshi et al., 2007; Szabo et al., 2002).”
• T Cell-Intrinsic Requirement for NF-κB Induction in Postdifferentiation IFN-γ Production and Clonal Expansion in a Th1 Response1 (2003, background): “The T-box transcription factor T-bet is critical for the emergence of a differentiated Th1 population in vitro and in vivo, and induction of this protein is promoted by Stat4 (10, 11).”
• Vaccines: Effector and memory T-cell differentiation: implications for vaccine development (2002, neutral): “The differential requirements for co-stimulatory molecules in CD4+ and CD8+ T-cell responses indicate that distinct mechanisms are involved in developing effector CD8+ and CD4+ T cells, as described recently by Szabo et al.40.”
• Interleukin-12 and the regulation of innate resistance and adaptive immunity (2003, background): “Interestingly, T-bet-deficient mice have a dominant expression of T H 2 cytokine”
• Similarities and differences in CD4+ and CD8+ effector and memory T cell generation (2003, background): “Also, it is notable that T-bet, the main transcription factor controlling T H 1 differentiation, has little effect on the generation of CD8 + IFN-γ-producing T cell”