Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

By I. Goshen, T. Kreisel, O. Ben-Menachem-Zidon, T. Licht, J. Weidenfeld, T. Ben-Hur, R. Yirmiya. Molecular Psychiatry, 2008

740 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Neurology

View Paper: https://www.semanticscholar.org/paper/79deda439064c74f8cfea8c437adfc432df9a9bf

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Citations in the corpus

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. (2011, background): “There is also evidence that neurodegeneration is characteristic of depression (Goshen et al., 2008; Campbell and MacQueen, 2006; Stockmeier et al., 2004; Duman, 2002).”
Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, neutral): “Depression is often the consequence of severe chronic stress and, as mentioned above, proinflammatory cytokines such as IL-1b also appear to be involved in the reduction of neurogenesis in animal models of depression (Goshen et al., 2008; Koo and Duman, 2008).”
Depression as a microglial disease. (2015, background): “be mediated by the secretion of IL-1 because both acute and chronic IL-1b administration impaired hippocampal neurogenesis [109,110], whereas pharmacological, surgical, or genetic procedures for IL-1 blockade prevented both the neurogenesis suppression and the depression-like effects induced by acut”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “BDNF) and decreased neurogenesis that is associated with chronic stress (while also reversing stressinduced behavioral changes) (Ben Menachem-Zidon et al., 2008; Goshen et al., 2008; Koo and Duman, 2008).”
Dopamine System Dysregulation in Major Depressive Disorders (2017, background): “…due to activation of pedunculopontine tegmental nucleus (PPTg) afferents. exposed to CMS show elevated hypothalamo-pituitary-adrenal axis activity (Goshen et al., 2008), decreased dendritic tree of hippocampal (Sousa et al., 2000) and cortical (Liu and Aghajanian, 2008; Li et al., 2011) pyramidal…”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “is indirect, via IL-1-induced glucocorticoids secretion (Goshen et al., 2008) (this mechanism will be discussed below, see Sec-”
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression (2009, background): “In animal models of depression, rodents were found to display reduced hippocampal neurogenesis (Goshen et al. 2008; Koo and Duman 2008) along with decreases in the levels of BDNF in brain regions associated with depression (Schmidt and Duman 2007; Fuchs et al. 2004).”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, neutral): “Strongly supporting a causative role for inflammatory mediators in these behavioral and neurobiological changes are studies showing that the effects of acute and chronic stress on behavior, cognition, neurotrophic factors, and neurogenesis can be prevented by blockade of CNS cytokine activity throug”
Neuroinflammation and depression: A review (2020, background): “Conversely, chronic IL-1β infusion into the dorsal hippocampus of mice for 4 weeks via osmotic mini-pumps decreased the number of hippocampal immature new-born neurons (Goshen et al., 2008).”