BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood

By A. Dzionek, A. Fuchs, P. Schmidt, S. Cremer, Monika Zysk, S. Miltenyi, D. Buck, J. Schmitz. Journal of Immunology, 2000

1,402 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/79a629468d1be5b1d1fa86a1dd3ed775b38e36bf

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In Immunology

1. Jacques Banchereau
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3. V. Pascual
4. M. Colonna
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6. O. Joffre
7. C. Reis e Sousa
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Citations in the corpus

• Immunology of Psoriasis (2014, background): “A panel of blood dendritic cell antigen (BDCA) antibodies was developed (22), with BDCA-1 (CD1c) and BDCA-3 (CD141) identifying distinct circulating myeloid DC subsets.”
• Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells (2012, background): “In addition to plasmacytoid DCs (pDCs), human blood harbors two subsets of CD11c myeloid DCs: a major CD1c (BDCA-1) population and a discrete CD141 (thrombomodulin or BDCA-3) subset (Dzionek et al., 2000; MacDonald et al., 2002; ZieglerHeitbrock et al., 2010).”
• Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA (2005, methodology): “Cell fractionation studies using the markers BDCA4 (refs”
• BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction (2001, methodology): “After several rounds of MACS ® and finally FACS ® using anti BDCA-2 mAb AC144 (19), plasmid DNA of a positive clone (H4#10A) was purified and sequenced.”
• C-type lectin receptors on dendritic cells and langerhans cells (2002, neutral): “It is now well appreciated that there are other subsets of DCs apart from myeloid DCs and LC”
• Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. (2003, methodology): “Supernatants were then tested by(Dzionek et al., 2000), which removed 95% of pDCs identified as CD123 CD11c HLA-DR cells lacking ELISA for both influenza-specific antibodies and total immunoglobulins.”
• OMIP-044: 28-color immunophenotyping of the human dendritic cell compartment (2018, methodology): “For gating on established DC subsets the markers CD11c, HLA-DR, CD141 (also known as BDCA-3, marks cDC1), CD1c (BDCA-1, marks cDC2), and CD123 (pDC) were used (14,15).”
• Dendritic cells as therapeutic vaccines against cancer (2005, background): “; interstitial DCs express DC-SIGN (dendritic-cell-specific intercellular-adhesion-molecule-3-grabbing non-integrin), which is involved in interactions with T cells and in DC migration but is also used by pathogens (such as HIV) to hijack the immune system; and pDCs express yet another lectin, BDCA2”
• Human inflammatory dendritic cells induce Th17 cell differentiation. (2013, background): “Blood conventional DCs can be separated into BDCA1 and BDCA3 DCs (Dzionek et al., 2000).”
• Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells (2010, background): “For example, BDCA2 is a marker for circulating human pDCs, whereas BDCA3 (also known as CD141 or thrombomodulin) marks a distinct small subset of blood DCs (Dzionek et al., 2000; MacDonald et al., 2002).”