TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

By Yong‐jun Liu, V. Soumelis, N. Watanabe, T. Ito, Yui-Hsi Wang, R. D. Malefyt, M. Omori, Baohua Zhou, Steven F. Ziegler. Annual Review of Immunology, 2007

686 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/79183f00055cebb62c6104eb47cf39b0baaaab6e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. G. Barton
2. R. Medzhitov
3. H. Hammad
4. B. Lambrecht
5. P. Barnes
6. Caroline L. Sokol
7. Shizuo Akira
8. Jonathan C. Kagan

In Physiology

1. H. Hammad
2. B. Lambrecht
3. P. Barnes
4. R. Medzhitov
5. Caroline L. Sokol

Citations in the corpus

• A mechanism for the initiation of allergen-induced T helper type 2 responses (2008, background): “TSLP is involved in lymphocyte development, but it can also be produced by epithelial cells, leading to T H 2 cell recruitment and allergic inflammatio”
• The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “gramming airway DCs to release the Th2 chemoattractants CCL17 and CCL22 and thus is important in recruiting Th2 cells to the airways (63).”
• Recognition of microorganisms and activation of the immune response (2007, background): “The mechanisms of T H 2-cell generation are unknown but presumably follow a similar principle, with the dedicated cytokines likely to be IL-4 and thymic stromal lymphopoietin (TSLP), produced in response to engagement of an unidentified sensor after helminth infectio”
• Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “TSLP is a 140-amino-acid IL-7-like four-helix-bundle cytokine that has the capacity to potently modulate DCs by binding its receptor complex, which is composed of the IL-7 receptor (IL-7R) and the TSLP receptor (TSLPR”
• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “We also discuss another cytokine that is not a member of the γ c family but that has overlapping functions with IL-7, known as thymic stromal lymphopoietin ( TSLP”