Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

By Yingwu Xu, X. Tao, B. Shen, T. Horng, R. Medzhitov, J. Manley, L. Tong. Nature, 2000

854 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/78f5b4eb37b14bed9297f29783b435bba025a71e

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In Immunology

In Microbiology

Citations in the corpus

Role of Toll-Like Receptors in Pathogen Recognition (2003, background): “The LPSd nonresponder phenotype of CH3/HeJ mice results from a Pro3His mutation at the 2 position in this loop in the TIR domain of TLR4, which impairs interaction with the adaptor signaling protein MyD88, resulting in abrogation of the LPS response ( 84 ).”
Plant NBS-LRR proteins: adaptable guards (2006, background): “Oligomerization of animal NOD proteins through the NBS domain or oligomerization of Toll-like receptors through the TIR domain is important for activating the signaling pathway in animal innate immune systems [60-64], but there are currently few data on the oligomerization of plant NBS-LRR proteins.”
Molecular Basis of NF-κB Signaling (2013, background): “The TIR domain forms a small, globular, parallel β-sheet surrounded by α-helices (25, 80, 123) (Figure 6c).”
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction (2001, methodology): “Predictions of the secondary structure of Mal, carried out using the PHD secondary structure prediction program, are consistent with the crystal structure of the TIR domain of TLR-2 (ref”
TLR3: interferon induction by double-stranded RNA including poly(I:C). (2008, background): “A substituted mutant A795H, in which an alanine residue in the B–B loop of the TIR domain of TLR3 is replaced with a histidine residue [50], does not activate NF-κB and the IFN-β promoter in HEK293 cells upon poly(I:C) stimulation because of its failure to bind TICAM-1 [12].”
The Structural Biology of Toll-Like Receptors (2011, background): “The crystal structures of isolated TIR domains have been reported for TLRs 1, 2 (Xu et al., 2000) and 10 (Nyman et al.”