Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

By W. Heath, G. Belz, G. Behrens, Christopher M. Smith, S. Forehan, I. Parish, G. Davey, N. Wilson, F. Carbone, J. Villadangos. Immunological Reviews, 2004

830 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/784c31c22efbf26e33626b53872c3d5a6f2cfb1d

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Citations in the corpus

• NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “Phagocytosed antigens are presented to CD8+ T lymphocytes through a process called ‘‘crosspresentation’’ (Guermonprez et al., 2002; Heath et al., 2004).”
• Toll-like receptor 3 promotes cross-priming to virus-infected cells (2005, background): “jpg" NDATA ITEM> ]> Cross-presentation of cell-associated antigens plays an important role in regulating CD8 p T cell responses to proteins that are not expressed by antigen-presenting cells (APCs”
• Type I interferon is selectively required by dendritic cells for immune rejection of tumors (2011, neutral): “Moreover, although the CD8+ DC subset is particularly adept at antigen cross­presentation, evidence also exists that other non­DC immune subsets as well as nonhematopoietic stromal cells might be capable of cross­presenting exogenous antigen in some circumstances (Ackerman and Cresswell, 2004; Heat”
• Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “Numerous experimental systems including diverse vaccination and immunization strategies, and models of infection, transplantation, tumor immunity, and autoimmunity have assigned important functions to CD8+ cDCs (Heath et al., 2004; López-Bravo and Ardavin, 2008).”
• Cutting Edge: Generation of Splenic CD8+ and CD8− Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures1 (2005, background): “Crosspresentation, a process whereby exogenous Ags are taken up and presented via MHC I, is conducted efficiently by splenic CD8 cDC but not CD8 DC nor pDC (19, 26).”
• Steady-state and inflammatory dendritic-cell development (2007, background): “and the presentation of antigens on MHC class I molecule”
• Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “CD8a cDCs cross-present antigens, a process in which exogenous antigen is presented to T cells by MHC class I molecules to activate cytotoxic CD8 T cells (Heath et al., 2004), so presentation of viral antigen by CD8a cDCs does not necessarily require direct infection.”
• The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “CD8+ cDCs are more potent at cross-presenting soluble and cell-associated antigens to CD8+ T cells when compared with CD8CD11b+ cDCs (Heath et al., 2004).”
• Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells (2009, background): “DCs can be categorized into many independent subsets that seem to represent end-stage population”