Toll-like receptor 3 promotes cross-priming to virus-infected cells

By O. Schulz, S. Diebold, M. Chen, T. Näslund, M. Nolte, L. Alexopoulou, Y. Azuma, R. Flavell, P. Liljeström, C. Reis e Sousa. Nature, 2005

957 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e9d9812e594dd7bb17f934cef42120fb813735bb

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. R. Medzhitov
4. Daniel B. Stetson
5. R. Randall
6. S. Goodbourn
7. O. Takeuchi
8. H. Hemmi

Citations in the corpus

• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “However, in the first case, we have reported at least one mechanism whereby DCs can be directly activated by viral PAMPs within the virally infected cell (97).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “…under some circumstances, pDCs can respond through TLR3 to the dsRNA presented 4 Journal of General Virology 89 Downloaded from www.microbiologyresearch.org by IP: 54.70.40.11 On: Thu, 06 Dec 2018 10:52:31 in the phagocytosed apoptotic cells derived from viral infection (Schulz et al., 2005).”
• Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “For example, the ISD ligands that accumulate inside a Trex1deficient cell undergoing apoptosis could become TLR9 ligands after phagocytosis of that cell by a macrophage or dendritic cell, akin to what was recently shown for viral RNA (Schulz et al., 2005).”
• Evasion of intracellular host defence by hepatitis C virus (2005, background): “Exogenous/extrahepatic immune effector cells that infiltrate the liver, including IFN-producing macrophages and dendritic cell”
• Innate immune recognition of viral infection (2006, background): “The dsRNA in the apoptotic bodies is recognized by TLR3, triggering the maturation of immature CD8α + DCs that are required for subsequent induction of antigen-specific CD4 + and CD8 + T cell response”