Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

By S. Bedoui, Paul G. Whitney, Jason Waithman, L. Eidsmo, L. Wakim, I. Caminschi, R. Allan, Magdalena Wojtasiak, K. Shortman, F. Carbone and 2 more. Nature Immunology, 2009

747 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4d3dd87b2bb2f130d7f6f29c92c16119677644f7

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In Immunology

1. O. Joffre
2. A. Sher
3. K. Murphy
4. R. Seder
5. R. Coffman
6. C. Reis e Sousa
7. Jacques Banchereau
8. K. Palucka

Citations in the corpus

• Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens (2010, background): “Despite their similarities, there are also notable differences between human CD141+ DCs and mouse CD8+ DCs. Unlike human CD141+ DCs, mouse CD8+ DCs express TLR4 and 9 and, thus, should respond differently to their ligands (Edwards et al., 2003).”
• Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “…have exhibited the specialized features of TLR3 responsiveness and the capacity for cross-presentation, suggesting a relationship with classical CD8+ DCs in lymphoid tissues, which themselves are CD103+CD11blow/neg DEC205+Langerinlow (Sung et al., 2006; del Rio et al., 2007; Bedoui et al., 2009).”
• Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “Moreover, mouse (Bedoui et al., 2009; Schulz et al., 2005) or human (Jongbloed et al., 2010; Poulin et al., 2010) DC subsets specialized for cross-presentation show increased CD8+ T cell immunity when Poly IC is used to activate cells through TLR3.”
• Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells (2010, background): “However, Batf3-dependent CD11b– CD103+ Langerin+ DCs related to CD8+ DCs have recently been identified in mouse peripheral tissues (Bedoui et al., 2009; Ginhoux et al., 2009; Edelson et al., 2010; Henri et al., 2010).”