An mRNA Surveillance Mechanism That Eliminates Transcripts Lacking Termination Codons

By P. Frischmeyer, A. van Hoof, Kathryn A. O’Donnell, A. Guerrerio, R. Parker, H. Dietz. Science, 2002

597 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/783a400858e5e0310be649d4c1ada9b5ead18961

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In Molecular Biology

Citations in the corpus

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “…arise when polyadenylation occurs prematurely within a coding region (Edwalds-Gilbert et al. 1997; Sparks and Dieckmann 1998; Graber et al. 1999; Frischmeyer et al. 2002), when transcription aborts (Cui and Denis 2003) or, at least in theory, upon incomplete 3 -to-5 decay of ribosome-associated…”
A large-scale analysis of mRNA polyadenylation of human and mouse genes (2005, background): “For example, (171, 37, 3) means that 171 type I genes, 37 type II genes and 3 type III genes.”
The enzymes and control of eukaryotic mRNA turnover (2004, background): “Similarly, in a process referred to as nonstop decay (NSD), mRNAs lacking translation termination codons are recognized and rapidly degraded 3′→5′ by the cytoplasmic exosom”
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy. (2017, background): “In the case of transcripts lacking a naturally occurring stop codon, the mRNA surveillance mechanism referred to as nonstop decay pathway identifies and releases the transcripts from ribosomes to prevent their translation.(78,79) This is followed by degradation of the released transcripts by the exo”
Cytoplasmic foci are sites of mRNA decay in human cells (2004, background): “Thus, NMD, NSD, and 3 –5 NMD allow the removal of aberrant mRNAs and unspliced pre-mRNAs in the cytoplasm that could be deleterious to the cell (He et al., 1993; Frischmeyer et al., 2002; van Hoof et al., 2002).”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “Another mechanism of mRNA quality control is the rapid 30 to 50 degradation of mRNAs that do not contain translation termination codons, which is referred to as non-stop decay (NSD) (Frischmeyer et al. 2002; van Hoof et al. 2002).”
RNA-quality control by the exosome (2006, background): “, whereas the non-stop decay pathway degrades mRNAs that lack a termination codon altogethe”
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5 (2003, background): “A premature stop codon is predicted by the frame shift and may result in a truncated protein or nonsense-mediated decay of the transcrip”