The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind*
By Yusuf A. Hannun, LM Obeid. Journal of Biological Chemistry, 2002
910 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/77b15e5471953c1f8702e9e94bfdf6950481b9e3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- A. Futerman
- Yusuf A. Hannun
- Ralph DeFronzo
- B. Ogretmen
- S. Alexander
- Hannah Alexander
- S. Summers
- Howard Riezman
In Physiology
- Ralph DeFronzo
- A. Futerman
- B. Ogretmen
- Yusuf A. Hannun
- Howard Riezman
- S. Summers
- M. Guzmán
- B. Vallée
Citations in the corpus
- The complex life of simple sphingolipids (2004, background): “This can be illustrated by again considering ceramide, which is at the centre of the pathways of sphingolipid synthesis and degradation (Hannun & Obeid, 2002).”
- Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. (2004, background): “Moreover, ceramide can be generated by hydrolysis of sphingomyelin, catalyzed by sphingomyelinase (21).”
- Cannabinoids: potential anticancer agents (2003, background): “— a lipid second messenger that can induce apoptosis and cell-cycle arres”
- “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “…to cell death (reviewed in Obeid et al., 1993) has been confirmed and extended by numerous reports, implicating these events in apoptotic responses to chemotherapeutic agents, ultraviolet and -irradiation, and many other cellular stresses (Kolesnick and Hannun, 1999; Hannun and Obeid, 2002).”
- Lipids in exosomes: Current knowledge and the way forward. (2017, background): “A possible explanation may be that nSMase has different subcellular localizations, resulting in ceramide formation at different locations [80,81].”
- Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. (2007, background): “The metabolic factors that induce insulin resistance almost invariably generate the sphingolipid ceramide (Summers and Nelson, 2005), which is a ubiquitous regulator of cellular stress (Hannun and Obeid, 2002).”