Cannabinoids: potential anticancer agents

By M. Guzmán. Nature Reviews. Cancer, 2003

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Synthon-based ligand discovery in virtual libraries of over 11 billion compounds (2021, background): “The approach is applied here to cannabinoid receptors, which are class A G-protein-coupled receptors (GPCRs), and are key targets in drug discovery for inflammatory disorders, neurodegenerative diseases and cancer 17–19 .”
The endocannabinoid system drives neural progenitor proliferation (2005, positive): “Cannabinoid actions on neural cell death and survival are not restricted to neurons, as glial cells are also targeted by CB1 activation (8).”
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. (2009, background): “, oral, oro-mucosal) (9, 36), our findings support that safe, therapeutically efficacious doses of THC may be reached in cancer patients.”
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “In general, an enhanced endocannabinoid system is seen in tumor tissues [179,182,183].”