The lysosome turns fifty

By C. Duve. Nature Cell Biology, 2005

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Cysteine cathepsins: From structure, function and regulation to new frontiers (2011, background): “Thus, in a short time, the lysosome concept was quickly accepted [2] [3] [4] [5] .”
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control. (2020, background): “…36 cells compared with their prokaryotic counterparts, including the development of endomembrane 37 systems such as lysosomes or vacuoles (de Duve, 2005), and the associated trafficking of materials 38 between these internal compartments and the plasma membrane via membrane-bound vesicles.”
Targeted protein degradation: mechanisms, strategies and application (2022, background): “In eukaryotic cells, damaged proteins or organelles can be cleared by proteasomes or lysosomes.(3,4) The two pathways are independent but inter-connected with each other.”
Signals for the lysosome: a control center for cellular clearance and energy metabolism (2013, background): “target of rapamycin complex 1 (mTORC1) on the lysosomal surface (1).”
Lysosomes: fusion and function (2007, background): “the phagosomal membrane and escape into the cytosol (1) with subsequent avoidance of”
Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB (2015, background): “Consistent with a role of MCOLN1 and lysosomal Ca2+ in the activation of calcineurin, the silencing of MCOLN1 significantly reduced the number of PI(3)P-positive vesicles (Fig.”