Signals for the lysosome: a control center for cellular clearance and energy metabolism
By C. Settembre, A. Fraldi, Diego L. Medina, Andrea Ballabio. Nature reviews. Molecular cell biology, 2013
1,576 citations recorded by the source corpus.
For a long time, lysosomes were considered merely to be cellular 'incinerators' involved in the degradation and recycling of cellular waste. However, now there is compelling evidence indicating that lysosomes have a much broader function and that they are involved in fundamental processes such as secretion, plasma membrane repair, signalling and energy metabolism. Furthermore, the essential role of lysosomes in autophagic pathways puts these organelles at the crossroads of several cellular processes, with significant implications for health and disease. The identification of a master regulator, transcription factor EB (TFEB), that regulates lysosomal biogenesis and autophagy has revealed how the lysosome adapts to environmental cues, such as starvation, and targeting TFEB may provide a novel therapeutic strategy for modulating lysosomal function in human disease.
Subfields: Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/2e2251714e959443a863898316cfb982ce1a09f4
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Citations in the corpus
- Brief update on endocytosis of nanomedicines (2019, background): “However, long overlooked as a static organelle, lysosomes are now known to be a dynamic hub of cellular activity, including cellular metabolism, nutrient sensing, subcellular localization-dependent pH control, plasma membrane repair, secretion, and spatiotemporal intracellular signaling [52,21,53,22”
- Molecular definitions of autophagy and related processes (2017, neutral): “More-over, lysosomal hydrolases also degrade lipids, sugars, and nucleic acids (Settembre et al , 2013).”
- Lysosomes as a therapeutic target (2019, background): “Besides being a degradative organelle, the lysosome has recently been recognized as a cellular signalling platform 3, 42 .”
- Recent insights into the function of autophagy in cancer (2016, background): “The MiT/ TFE family of transcription factors (TFE3, MITF, and TFEB) (Settembre et al. 2011, 2013) are upstream regulators of autophagy and lysosome function, which confers PDAC cells with increased catabolic capacity (Perera et al. 2015).”
- mTOR: a pharmacologic target for autophagy regulation. (2015, neutral): “74).”
- Endocytosis, Signaling, and Beyond (2014, background): “This observation led to the discovery that TFEB also regulates the autophagy pathway via the CLEAR network (Settembre et al. 2011, 2013a).”
- Lysosomal Physiology (2015, background): “Lysosome-mediated catabolic degradation is an adaptive process regulated by nutrient status and cellular signaling (6).”
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “Accordingly, TFEB overexpression rescues fat accumulation and metabolic syndrome in a diet-induced model of obesity.(823,825) The regulation of expression of lipid droplet regulators (such as the PLIN/perilipin family) and of autophagy adaptors (such as the TBC1D1 family) during starvation and disea”