A human protein-protein interaction network: a resource for annotating the proteome.

By Ulrich Stelzl, Uwe Worm, M. Lalowski, Christian Haenig, F. Brembeck, H. Goehler, Martin Stroedicke, Martina Zenkner, Anke Schoenherr, Susanne Koeppen and 13 more. Cell, 2005

2,471 citations recorded by the source corpus.

Subfields: Cell Biology, Computational Theory and Mathematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e6fdb242921ea9c09c588d3c943ee7f227dc269c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Computational Theory and Mathematics

In Molecular Biology

Citations in the corpus

A Protein Complex Network of Drosophila melanogaster (2011, neutral): “Given the fundamental importance of protein interactions, proteome-wide ‘‘interactome’’ maps based on pairwise protein interactions using the yeast two-hybrid (Y2H) system have been determined for several organisms (Giot et al., 2003; Ito et al., 2001; Li et al., 2004; Rual et al., 2005; Stanyon et ”
Integrative approaches for finding modular structure in biological networks (2013, background): “The past decade has witnessed an explosive growth in data on biological networks 9–14,16, 160, 161 , albeit with inherent Module-based biomarkers derived through integrative network analyses also provide superior predictive performance in disease classification, especially when compared with…”
A human phenome-interactome network of protein complexes implicated in genetic disorders (2007, background): “Additionally, only a few large-scale protein interaction studies have been finalized for the human proteom”
Perception of UV-B by the Arabidopsis UVR8 Protein (2011, methodology): “Gateway-based cloning was used to insert the UVR8 and COP1 coding regions in frame to the LexA DNA binding domain (BD) in pBTM116-D9 (5) (vector kindly provided by Ulrich Stelzl, Max Delbrück Center for Molecular Medicine, BerlinBuch) and to the GAL4 activation domain (AD) in pGADT7_GW vector (6) (k”
Human protein interaction networks across tissues and diseases (2015, background): “…section: This article was submitted to Systems Biology, a section of the journal Frontiers in Genetics Received: 28 May 2015 Accepted: 17 July 2015 Published: Citation: Yeger-Lotem E and Sharan R (2015) Human protein interaction networks across tissues and diseases.”
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization (2009, background): “Recent biotechnological advances such as the high-throughput yeast two-hybrid screen have facilitated building proteome-wide protein–protein interaction networks (PPINs) or ‘interactome’ maps in humans (18, 19 ).”
Biological network comparison using graphlet degree distribution (2007, neutral): “Large amounts of cellular network data for a number of organi sms have recently become available through high-throughput me thods (13; 35; 11; 19; 32; 29).”
HIPPIE: Integrating Protein Interaction Networks with Experiment Based Quality Scores (2012, methodology): “Additionally, we integrated interactions from manually selected studies [12,13,14,15,16,17,18,19,20,21,22]; interactions from these studies were integrated that were not contained in the public databases at the time of integrating the sources.”
NOA: a novel Network Ontology Analysis method (2011, background): “Currently, many biological networks have been extensively studied, such as protein interaction networks (13), gene regulatory networks (14) and metabolic networks (15).”
Handbook of Big Data (2016, background): “The basic operation is zooming and panning of a table that is presented in a graphical form, here called a blockplot .”
A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, methodology): “Y2H interaction screening was performed as described previously ( 17 , 18 ).”
Network Medicine: A Network-based Approach to Human Disease (2011, background): “Most attention has been directed towards molecular networks, including protein interaction networks, whose nodes are proteins that are linked to each other by physical (binding) interaction”
Structure-based prediction of protein-protein interactions on a genome-wide scale (2012, methodology): “H u m an Rual 2455 Y2H IntAct [43] Stelzl 2972 Y2H IntAct [44] Ewing 5504 AP/MS IntAct [22]”