Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells.

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Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “CDC42 can also function independently of the PAR complex through its target, myotonic-dystrophy-kinase-related CDC42-binding kinase (MRCK), to move the nucleus behind the MTO”
TAN lines (2011, background): “Several years ago we found that centrosome reorientation in wounded monolayers of NIH3T3 fibroblasts did not involve movement of the centrosome, as had been expected, but resulted from movement of the nucleus past a stationary centrosome.(10) Our initial findings indicated that this nuclear movement”
Non-muscle myosin II takes centre stage in cell adhesion and migration (2009, positive): “Data from experiments in which NM II activity was inhibited by blebbistatin reveal that NM II also regulates nucleus repositionin”
Random versus directionally persistent cell migration (2009, background): “CDC42 can promote directional cell motility in fibroblast scratch wound healing assays in vitro as cells migrate into a region denuded of cell”
Regulators of the cytoplasmic dynein motor (2009, background): “In migrating fibroblasts, dynein and LIS1–NUDEL are required to maintain the position of the MTOC during initial polarization, as well as the alignment of the mitotic spindle with the substratu”