Regulators of the cytoplasmic dynein motor

By Julia R. Kardon, R. Vale. Nature reviews. Molecular cell biology, 2009

658 citations recorded by the source corpus.

Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport activities as the many different types of kinesin. How is dynein coupled to its wide range of cargos and how is it spatially and temporally regulated? The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NUDE) and NUDE-like, Bicaudal D, Rod–ZW10–Zwilch and Spindly, that regulate dynein function and localization.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/00037a4e0c729e455ebc7c0eaea383d933869fbc

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Citations in the corpus

• Endosome maturation (2011, background): “In contrast to the large number of different kinesin motors, dynein is the only member of its family (Kardon and Vale, 2009).”
• Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “The dynein can transport diverse cargoes because of its regulation by many different molecular adaptors [692, 693].”