Cargo recognition and trafficking in selective autophagy

By Alexandra Stolz, Andreas M. Ernst, Ivan Dikic. Nature Cell Biology, 2014

1,151 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/760a0e5ac5cfaa77d558f0ca0ac97d006d40a726

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Sang Hun Lee
2. S. Martens
3. Ivan Dikic
4. C. Yun
5. R. Youle
6. B. Padman
7. M. Lazarou
8. Gabriele Zaffagnini

In Epidemiology

1. S. Martens
2. Gabriele Zaffagnini
3. R. Youle
4. M. Lazarou
5. Ivan Dikic
6. B. Padman
7. T. Nguyen
8. A. Ordureau

In Physiology

1. R. Youle
2. Sang Hun Lee
3. Ivan Dikic
4. C. Yun

Citations in the corpus

• Molecular definitions of autophagy and related processes (2017, neutral): “…et al , 2014), proteins that participate in mitophagy, such as SMURF1 (Orvedahl et al , 2011), Fanconi anemia complementation group C (FANCC) (Sumpter et al , 2016), and PEX13 (Lee et al , 2017), as well as the phosphorylation of eukaryotic translation initiation factor 2A (EIF2A) (Talloczy…”
• Autophagy in malignant transformation and cancer progression (2015, neutral): “Several receptors participate in the selective recognition and recruitment of autophagosomal cargoes in the course of targeted autophagic responses (Rogov et al , 2014; Stolz et al , 2014).”
• Triglyceride metabolism in the liver (2017, neutral): “The autophagosome formation relies on several autophagy receptors in addition to the autophagy-related proteins (ATGs) (241).”
• The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of TBK1 activation and recruitment of OPTN and NDP52 to promote mitophagy (2015, background): “…of cargo adaptor proteins such as SQSTM1 (also called p62), NBR1, NDP52 (also called CALCOCO2), Optineurin (OPTN), TAX1BP1, and NIX, each of which associate with ATG8 proteins via an LC3 interacting region (LIR) motif and with cargo via other domains (Stolz et al., 2014; Weidberg and Elazar, 2011).”
• Molecular mechanisms and physiological functions of mitophagy (2021, neutral): “…selective autophagy-related processes including mitophagy, a series of autophagy adaptors (p62/SQSTM1, NBR1, NDP52/ CALCOCO2, TAX1BP1, and OPTN) play important roles in selective uptake of cargoes (Johansen & Lamark, 2011; Mizushima & Komatsu, 2011; Stolz et al , 2014; Zaffagnini & Martens, 2016).”
• The Roles of Autophagy in Cancer (2018, background): “LC3 II is located in the inner and outer membrane of the autophagosome, enabling it to bind to degraded substrates [34,35,36].”
• Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria (2016, background): “Autophagy receptors function as decoders for the various ubiquitin signals on cargoes, linking cargoes to autophagosomal membranes (4); however, the basis of their individual recruitment to cargo as well as their distinct and cooperative functions in cargo sequestration are still poorly understood.”
• Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, neutral): “…homeostasis in non-starved cells by degrading cargo material, such as aggregate-prone proteins, including those causing many neurodegenerative conditions (aggrephagy), damaged mitochondria (mitophagy), excess peroxisomes (pexophagy) and invading pathogens (xenophagy) (Stolz et al., 2014).”