Brain dopamine and obesity.

By Gene-Jack Wang, Nora D. Volkow, Jean Logan, N. Pappas, Christopher T. Wong, Wel Zhu, Noelwah Netusll, J. S. Fowler. The Lancet, 2001

1,828 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/75980b55ade663460326274b396d46f4d3f42e19

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In Cellular and Molecular Neuroscience

In Clinical Psychology

In Endocrine and Autonomic Systems

Citations in the corpus

How can drug addiction help us understand obesity? (2005, result): “In humans, brain imaging studies show reductions in dopamine D2 receptors in the striatum of obese individuals that are similar in magnitude to the reductions reported in drug-addicted subject”
Pro v Con Reviews: Is Food Addictive? (2012, background): “Indeed, the negative correlation between BMI and striatal D2R reported in obese (81) and in overweight (96) individuals, as well as the correlation between BMI and decreased blood flow in prefrontal regions in healthy individuals (97,98) and decreased prefrontal metabolism in obese subjects (63) sup”
Widespread reward-system activation in obese women in response to pictures of high-calorie foods (2008, positive): “It is well established that rewarding effects of addictive drugs and natural reinforcers such as foods are mediated by a common neural substrate (Kelley and Berridge, 2002; Volkow and Wise, 2005; Wang et al., 2001; Wang et al., 2004b).”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “For example, PET neuroimaging studies have suggested that obese people may have lower levels of dopamine D2 receptor-binding in their brains' striatum than others [122,123].”
Preliminary validation of the Yale Food Addiction Scale. (2009, background): “In contrast, drugs activate the same reward system through direct pharmacological effects ( Volkow & Wang, 2005 ).”
Reward, dopamine and the control of food intake: implications for obesity (2010, neutral): “Preclinical and clinical studies have provided evidence of decreases in DA signaling in striatal regions [decreases in DAD2 (D2R) receptors and in DA release], that are linked with reward (NAc) but also with habits and routines (dorsal striatum) in obesity [56–58].”
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers (2003, result): “Although this is the first evidence that dopamine is released during feeding in humans, Wang and colleagues have used PET to show that the body mass index of obese individuals is negatively correlated with baseline [ 11 C]raclopride BP (Wang et al., 2001).”
Discovering Endophenotypes for Major Depression (2004, background): “…and peptides that play major roles in major depression, such as serotonin, norepinephrine, dopamine, neuropeptide Y, and corticotropin-releasing hormone, also play important roles in the regulation of food intake and body weight (Gillard et al, 1993; Meguid et al, 2000; Wang et al, 2001).”
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. (2008, result): “This decrease in D2 receptors in obese subjects is similar in magnitude to the reductions reported in drug-dependent subjects (Wang et al., 2001).”
Disorders of compulsivity: a common bias towards learning habits (2014, positive): “Similar to psychostimulant dependence, studies in obese humans demonstrate lower striatal dopamine D2 receptor binding along with lower prefrontal metabolism including the medial OFC (28).”