The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

By P. Cloos, J. Christensen, K. Agger, Alessio Maiolica, Juri Rappsilber, Torben L Antal, K. Hansen, K. Helin. Nature, 2006

755 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/753bed7652b34212d2cea05d655f2a7ec6fdd21d

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In Molecular Biology

1. Yang Shi
2. Yi Zhang
3. K. Helin
4. J. Whetstine
5. J. Christensen
6. Joshua C. Black
7. Capucine Van Rechem
8. P. Cloos

Citations in the corpus

• Regulation of histone methylation by demethylimination and demethylation (2007, background): “The function of JHDM3/JMJD2 proteins seem to be relevant to cancer biology, as the JHDM3C/JMJD2C protein is overexpressed in oesophageal cancer cell lines 84 and RNA interference (RNAi)-mediated knockdown of JHDM3C/JMJD2C reduces proliferation of these cell lines 78 .”
• JmjC-domain-containing proteins and histone demethylation (2006, background): “The JHDM3 and JMJD2 H3K9 and H3K36 demethylases regulate gene expression 16 , antagonize HP1 recruitment to chromatin 16–18 and are required for the proliferative capacity of specific cancer cell lines 17 .”
• ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs (2011, positive): “Moreover, the enzymatically-inactive KDM4C-H190G/E192A mutant (Cloos et al., 2006) failed to demethylate Pc2K191me2 (Figures 2B and S2C).”
• Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact (2012, positive): “…to demethylate trimethylated lysines; however, this lack of activity was remedied by the discovery of the first tri-demethylase family, KDM4A-KDM4D (also known as JMJD2A-JMJD2D) (Figure 1A) (Cloos et al., 2006; Fodor et al., 2006; Klose et al., 2006; Trojer et al., 2009; Whetstine et al., 2006).”
• DNA hypomethylation and human diseases. (2007, background): “Mouse knock out experiments have demonstrated that loss of methylation at H3K9 results in marked genomic instability and increases cancer predisposition [157].”
• Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. (2008, background): “org Volume 118 Number 6 June 2008 dent upon the presence of an iron-binding domain (34, 35), which would be inactivated under conditions of oxidative stress that are present in IUGR islets (5).”
• Histone methylation: a dynamic mark in health, disease and inheritance (2012, neutral): “KDM5A (JARID1A, RBP2, RBBP2) H3K4me2, H3K4me3 12p11 NUP98 t(11;21;12)(p15;p13;p13) Acute myeloid leukaemia”