Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

By Joshua C. Black, Capucine Van Rechem, J. Whetstine. Molecules and Cells, 2012

1,173 citations recorded by the source corpus.

Histone lysine methylation has emerged as a critical player in the regulation of gene expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a tremendous amount of progress has led to the characterization of methyl modifications and the lysine methyltransferases (KMTs) and lysine demethylases (KDMs) that regulate them. Here, we review the discovery and characterization of the KMTs and KDMs and the methyl modifications they regulate. We discuss the localization of the KMTs and KDMs as well as the distribution of lysine methylation throughout the genome. We highlight how these data have shaped our view of lysine methylation as a key determinant of complex chromatin states. Finally, we discuss the regulation of KMTs and KDMs by proteasomal degradation, posttranscriptional mechanisms, and metabolic status. We propose key questions for the field and highlight areas that we predict will yield exciting discoveries in the years to come.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3271ea822788d9e2afe130a4a902b28ec90610fd

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Citations in the corpus

• Histone Modifications and Cancer. (2016, background): “It is important to note that, whereas many of the methyltransferases and demethylases are amplified, overexpressed, deleted, misregulated, rearranged, or mutated, their direct causality on cancer as a result of changes to lysine methylation has not been broadly shown (Black et al. 2012).”
• H3K4me3 breadth is linked to cell identity and transcriptional consistency (2014, background): “H3K4me3 is deposited by members of the COMPASS/ Trithorax/Trithorax-related family of methyltransferase complexes and removed by the JARID1 family of demethylases (Black et al., 2012).”