Histone methylation: a dynamic mark in health, disease and inheritance

By E. L. Greer, Yang Shi. Nature reviews genetics, 2012

2,118 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/49a73cdf5421995fc48f0b1c020c9c0ec844195f

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In Molecular Biology

Citations in the corpus

Methylation multiplicity and its clinical values in cancer (2021, positive): “Lysine methylation could either activate or repress gene expression, depending on the location and degree of methylation (Refs 38, 41 – 44 , 46 ).”
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact (2012, positive): “Deletion of kmt1d (located in 9q34) or substitution within the protein have been linked to mental retardation, epileptic seizures, and autism (Greer and Shi, 2012).”
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. (2013, background): “Accordingly, reduced H3K27me3 levels are associated with unfavorable prognosis in breast, ovarian, and pancreatic cancers (Greer and Shi, 2012; Wei et al., 2008).”
DNA methylation on N6-adenine in C. elegans (2015, positive): “This includes proteins, noncoding RNA, and modifications to both proteins and DNA in chromatin (Greer and Shi, 2012; Martin and Zhang, 2007; Moazed, 2011).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “LSD1 utilizes FAD (also known as vitamin B2) as a cofactor to oxidize the methylated lysine ε-amino to remove methyl groups and produce FADH2 (Shi et al., 2004; Anand and Marmorstein, 2007; Greer and Shi, 2012), but LSD1 catalyzes only the removal of methyl groups on mono- or dimethylated lysine res”
Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “Methylation of arginine and lysine residues on histones or nonhistone proteins such as TFs regulate chromatin structure and therefore gene expression (Greer and Shi, 2012).”
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism (2015, background): “Alterations in the methylation status of proteins, nucleic acids, and metabolites contribute to the pathogenesis of many of the major human pathophysiological conditions including cancer, obesity, and aging (Bergman and Cedar, 2013; Greer and Shi, 2012; Kraus et al., 2014).”