Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells

By Kevin V. Morris, S. Chan, Steven E Jacobsen, D. Looney. Science, 2004

899 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/745f9b1310445f3987529803422ded8160fb6bd5

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Citations in the corpus

DNA Methylation and Its Basic Function (2013, positive): “One hypothesis suggests that RNA interference (RNAi) mechanisms target Dnmts to silence specific sequences of DNA (Morris et al, 2004).”
The rise of regulatory RNA (2014, positive): “…post-transcriptionally and cytoplasmically, but the existence of Ago in the nucleus 84–87 and the role of the RNAi pathway in epigenetic modulation 88 suggests that the system is more complex and multifaceted than expected, with (for example) demonstrations that miRNA isoforms are developmentally…”
RNA meets chromatin. (2005, positive): “Two recent reports have suggested that gene silencing, mediated by DNA methylation, can be induced by promoter-directed siRNAs in mammalian cells (Kawasaki and Taira 2004; Morris et al. 2004).”
Chitosan-based formulations for delivery of DNA and siRNA. (2010, positive): “In comparison to conventional DNA-based gene therapy, the use of small interfering RNA (siRNA) for gene silencing by the method of RNA interference (RNAi) has recently attracted much attention [67].”
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, neutral): “It has been shown that promoter-targeting siRNAs can induce TGS in cultured human cell lines as well (Morris et al, 2004), and recently an endogenous mammalian TGS mechanism involving miRNAs has been proposed (Gonzalez et al, 2008; Kim et al, 2008).”
Cancer epigenetics. (2005, positive): “Recent reports of transcriptional silencing and promoter DNA methylation induced by small interfering RNAs in human cells raise the interesting prospect of an involvement of microRNAs in epigenetic silencing in cancer cells (149,150) (Mattick, this issue).”
Perspective: machines for RNAi. (2005, positive): “2004) and perhaps even in mammals (Kawasaki and Taira 2004; Morris et al. 2004).”
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. (2006, positive): “Although siRNA-mediated DNA modification and chromatin remodeling are controversial in mammals (Morris et al. 2004; Park et al. 2004; Svoboda et al. 2004b; Kanellopoulou et al. 2005; Murchison et al. 2005), it is tempting to speculate that differential expression of retrotransposons and subsequent p”
Non-coding RNA. (2006, positive): “In agreement with this prediction small RNAs have been shown to induce transcriptional silencing and alterations to DNA methylation in human cells (169,170).”
DNA methylation: The nuts and bolts of repression (2007, neutral): “Cell culture studies have shown that RNAi-mediated silencing can lead to de novo methylation (Morris et al., 2004).”