Trk receptors: mediators of neurotrophin action.

By Ardem Patapoutian, L. Reichardt. Current Opinion in Neurobiology, 2001

1,115 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/73f5a735cd74b31ce52c117fc99d40df1984fb7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. B. Lu
2. M. Chao
3. Undurti N. Das
4. Siresha Bathina
5. G. Brodeur
6. C. Bramham
7. L. Reichardt

In Cellular and Molecular Neuroscience

1. B. Lu
2. L. Reichardt
3. Undurti N. Das
4. Siresha Bathina
5. M. Chao
6. H. Scharfman
7. D. Binder
8. G. Brodeur

In Molecular Biology

1. B. Lu
2. M. Chao
3. G. Brodeur
4. L. Reichardt
5. D. Binder
6. Undurti N. Das
7. Volkmar Lessmann
8. C. Bramham

Citations in the corpus

• BDNF and activity-dependent synaptic modulation. (2003, background): “Activated receptors in general are capable of triggering a number of signal transduction cascades including the MAPK pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, and the phospholipase C- (PLC- ) pathway (Kaplan and Miller 2000; Patapoutian and Reichardt 2001).”
• Brain-derived neurotrophic factor and its clinical implications (2015, background): “Trk receptor-mediated signaling is controlled through expression of intermediates in these signaling pathways that regulate localization of different signaling constituents [21–23].”
• Neurotrophin secretion: current facts and future prospects. (2003, background): “…between so called neuronal cell lines and primary neurons have often been described (see, e.g. PC12 cell survival versus neuronal survival; reviewed inKaplan and Miller, 2000; Patapoutian and Reichardt, 2001), and mixing up these two sets of data for NT secretion thus seems not to be appropriate.”
• Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “In addition to forming complexes, Trk and p75 receptors show independent signalling propertie”
• BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. (2005, background): “A growing body of evidence suggests an increase in the diversity and subcellular specificity of TrkB-coupled signaling pathways with maturation of the nervous system (Qian et al., 1998; York et al., 2000; Patapoutian and Reichardt, 2001).”
• Brain-derived neurotrophic factor. (2004, background): “Ligand-induced receptor dimerization results in kinase activation; subsequent receptor autophosphorylation on multiple tyrosine residues creates specific binding sites for intracellular target proteins, which bind to the activated receptor via SH2 domains (Barbacid, 1994; Patapoutian and Reichardt, ”
• Neurotrophin-regulated signalling pathways (2006, background): “Several excellent reviews describe recent progress in understanding the developmental and functional roles of these proteins (Bibel & Barde 2000; Huang & Reichardt 2001; Patapoutian & Reichardt 2001; Sofroniew et al. 2001; Dechant & Barde 2002; Chao 2003; Chao & Lee 2004; Lu et al. 2005).”
• Corneal nerves: structure, contents and function. (2003, background): “Mature neurotrophins exert their biological functions by binding to and activating two types of structurally unrelated transmembranous receptors: the low affinity p75 neurotrophin receptor (p75) and four members of the high affinity Trk receptor family of tyrosine kinases (Patapoutian and Reichardt,”
• Neuroblastoma: biological insights into a clinical enigma (2003, background): “cgi?l=4909">NT4 , also known as NT5) also seems to function through Trk”