Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis

By L. Borsig, Richard Wong, J. Feramisco, David R. Nadeau, N. Varki, A. Varki. Proceedings of the National Academy of Sciences of the United States of America, 2001

736 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/73e8715a2793bcaba5a447e19fb0dd7ebb52a76a

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Citations in the corpus

Inflammation and cancer (2002, neutral): “P-selectin facilitates human carcinoma metastasis in immunodeficient mice by mediating early interactions of platelets with blood-borne tumour cells via their cell-surface mucins, a process that can be blocked by hepari”
Fucose: biosynthesis and biological function in mammals. (2003, background): “…mechanisms for sialyl Lewisx=a-mediated metastasis include formation of cellular thromboemboli via interaction with platelet-borne P-selectin (Borsig et al., 2001) and blockade of leukocytic infiltration into tumors by secretion of sialyl Lewisx=a-containing inhibitors of…”
A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. (2007, background): “Although we have not identified specific cell adhesion molecules involved in cell–cell interactions, we hypothesize that, similarly to heparin (Borsig et al. 2001), fucoidans could initially block P-selectinmediated cell adhesion.”
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. (2001, background): “While the mechanism underlying this correlation is in need of study, treatment with low molecular weight heparin has been observed to confer a lower mortality rate on cancer patients (35).”
Contribution of platelets to tumour metastasis (2011, background): “Leukocytes and natural killer (NK) cells are found in close proximity to these metastasizing cell”
Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “Several studies show that platelets cover tumor cells, offering protection from cytolysis by natural killer cells (Nieswandt et al., 1999; Borsig et al., 2001).”
The sweet and sour of cancer: glycans as novel therapeutic targets (2005, background): “modifying enzymes [9, 19, 92, 175], as well as antibodies or glycan-coated nanoparticles for cell-directed therapy”
Brain metastases: epidemiology and pathophysiology (2005, background): “In some tumors, P-selectin, an adhesion molecule, plays an important role in formation of these complexes [70]; heparin inhibits p-selectin and decreases metastases in some experimental models [70].”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, positive): “The most direct evidence for the involvement of P-selectin (which is present on activated platelets and the endothelium) in the metastatic process is the marked inhibition of metastasis in P-selectin-knockout mice compared to wild-type controls in a colon carcinoma xenograft mode”