Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.

By I. Vlodavsky, Y. Friedmann. Journal of Clinical Investigation, 2001

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Roles of heparan-sulphate glycosaminoglycans in cancer (2002, background): “cgi?Q=hpse%20or%20hpa2&ORG=Hs">heparanases and the invasiveness of tumour cell”
Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “It is the first functional mammalian HS-degrading enzyme that has been characterized, which may lead to the identification and cloning of other glycosaminoglycans-degrading enzymes (Vlodavsky and Friedmann, 2001; Vlodavsky et al., 2002).”
Overview of the matrisome--an inventory of extracellular matrix constituents and functions. (2012, background): “Further details of structure and functions of various heparan sulfate 4 Cite this article as Cold Spring Harb Perspect Biol 2012;4:a004903 proteoglycans are discussed by Bishop et al. (2007) and Sarrazin et al. (2011).”
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, positive): “Thus, Noxs control developmental signaling in the most primitive multicellular organisms, an ancestral function that foreshadowed their later involvement in basic mammalian cell fate pathways.”