Contribution of platelets to tumour metastasis

By Laurie J. Gay, B. Felding‐Habermann. Nature Reviews. Cancer, 2011

1,595 citations recorded by the source corpus.

Subfields: Internal Medicine, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/41f2e55914d80eb8c00ae86dfeb1e7eeb0fdb964

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In Molecular Biology

1. E. Batlle
2. F. Giancotti
3. Jonathan M Cooper
4. X. Zhang
5. C. Nadal
6. J. Massagué
7. R. Hynes
8. Shahinoor Begum

In Oncology

1. J. Massagué
2. E. Batlle
3. X. Zhang
4. Jonathan M Cooper
5. Jong-Sup Bae
6. R. Hynes
7. Shahinoor Begum
8. F. Giancotti

Citations in the corpus

• Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis (2011, background): “…lysis (Nieswandt et al., 1999; Palumbo et al., 2005), limits their exposure to shear stress, and promotes their adhesion to the endothelium (Erpenbeck and Scho¨n, 2010; Gay and Felding-Habermann, 2011; Im et al., 2004; Jain et al., 2007; Karpatkin et al., 1988; Sierko and Wojtukiewicz, 2007).”
• RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics (2015, neutral): “672 Cancer Cell 28, 666–676, November 9, 2015 a2015 The Authors Blood platelets are widely involved in tumor growth and cancer progression (Gay and Felding-Habermann, 2011).”
• Dependency of colorectal cancer on a TGF-beta-driven programme in stromal cells for metastasis initiation (2012, background): “Platelets protect circulating tumor cells from immune system, aswell as assist themduring extravasation (Gay and Felding-Habermann, 2011).”
• Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment (2016, background): “α-granule is a storage of proteins that enhance adhesive process, angiogenesis, and extracellular matrix (ECM) degradation [81].”
• Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “Virtually every step in the breast cancer metastatic process can be linked to normal platelet function.(48) Determining the mechanism of action of aspirin in breast cancer and identifying the specific cells targeted by aspirin will allow development of therapeutic protocols that couldmitigate the ri”
• Nanomedicine in cancer therapy (2023, background): “323 These platelet aggregates shield CTCs from the shear stress of fl owing blood and the elimination by natural killer (NK) cells.”
• Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “Platelet- and fibrin-rich thrombi adhere to the αvβ3 integrin on CTCs, effectively shielding them from shear stress and from immune recognition by NK cells (Degen and Palumbo, 2012; Gay and Felding-Habermann, 2011).”