Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

By Spencer C. Liang, Y. Latchman, J. Buhlmann, Michal Tomczak, B. Horwitz, G. Freeman, Arlene H. Sharpe. European Journal of Immunology, 2003

683 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/7399dc8bad9cf78a059d06a95e26ef18629c0718

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Citations in the corpus

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression (2004, background): “and -negative thymocytes, activated T and B cells, and myeloid cells (9, 10, 14, 15).”
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection (2007, background): “In the thymus, PD-L1 is expressed broadly in the cortex, whereas PD-L2 expression is restricted to medullary stromal cell”
PD-1 and its ligands in tolerance and immunity. (2008, background): “In the NOD mouse model of autoimmune T cell–mediated diabetes, PDL1 is upregulated in the pancreas on islet cells (31), and loss or blockade of PD-1 or PD-L1 leads to rapid and exacerbated diabetes with accelerated insulitis and proinflammatory cytokine production by T cells (61– 63).”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “Liang SC, et al. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.”
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. (2014, neutral): “Type I IFNs can induce PD-L1 expression, which is proposed to limit local immunity and promote tumor relapse.”
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, background): “Although minimal expression of PD-L1 and PD-L2 has been reportedly observed within GC (53), the use of more sensitive detection techniques will be required to clarify this issue.”
Regulatory mechanisms of PD-1/PD-L1 in cancers (2024, background): “PD-L1 is widely expressed in antigen-presenting cells and tissues, such as heart and lung [2, 3].”
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways (2008, background): “PD-L1 is broadly expressed in the thymus cortex, while PD-L2 is limited to medullary stromal cells (24, 57).”
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “PD-L1 is expressed by immune and nonimmune cells, including tumor cells, whereas PD-L2 is expressed by DCs, macrophages, and germinal center B cells (49, 216).”