B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

By J. Konishi, K. Yamazaki, M. Azuma, I. Kinoshita, H. Dosaka-akita, M. Nishimura. Clinical Cancer Research, 2004

729 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c0bd4c1028319181ef7db1557fabd591e4b5a6e8

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Citations in the corpus

The blockade of immune checkpoints in cancer immunotherapy (2012, background): “Forced expression of PDL1 on mouse tumour cells inhibits local antitumour T cell-mediated response”
Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T Cell Rejection Function in Tumors (2013, background): “Mechanisms regulating immune activation in cancer progression have been extensively investigated (4-16).”
Inhibitory B7-family molecules in the tumour microenvironment (2008, background): “Some reports have shown that B7-H1 expression on tumour cells might also be associated with decreased numbers of tumour-infiltrating lymphocytes in patients with cance”
The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. (2006, background): “Moreover, the expression of B7-H1 has been described in several malignancies, including ovary cancer, colon cancer, melanoma, and lung carcinoma [13]; squamous cell carcinoma of the head and neck [16]; glioma [20]; non–small cell lung carcinoma [21]; renal cell carcinoma [22]; and, recently, esophag”
PD-L1 expression in human cancers and its association with clinical outcomes (2016, neutral): “No correlation between PD-L1 expression and patient survival Konishi et al 81 Significant correlation was found between the infiltration of Foxp3”
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation (2011, background): “Expression of PD-L1 on lung cancer cells has ever been confirmed as an activator of antigen-specific T cell [28].”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “…of PD-L1 expression strongly correlate with unfavorable prognosis in several cancers (Dong et al., 2002; Iwai et al., 2002; Strome et al., 2003; Konishi et al., 2004; Thompson et al., 2004; Blank et al., 2005; Hirano et al., 2005; Ohigashi et al., 2005; Dorfman et al., 2006; Wu et al., 2006;…”