Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.

By Liufu Deng, H. Liang, Byron Burnette, M. Beckett, T. Darga, R. Weichselbaum, yang-xin fu. Journal of Clinical Investigation, 2014

1,925 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/f9100f64233bef13091284caa33aaecdf3756ca5

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Citations in the corpus

STING-dependent Cytosolic DNA Sensing Promotes Radiation-induced Type I interferon-dependent Antitumor Immunity in Immunogenic Tumors (2014, methodology): “Our previous studies have shown that adaptive immune responses play a role in the antitumor effect of radiation alone or combined with immunotherapy (Deng et al., 2014; Lee et al., 2009; Liang et al., 2013).”
PD-L1 expression in human cancers and its association with clinical outcomes (2016, neutral): “Deng et al 54 demonstrated that tumor PD-L1 expression is upregulated after irradiation in mouse models.”
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory (2019, methodology): “This pool could explain why unlike the TRAMPC2 model, the MC38 model is partially responsive to anti-PD-L1 antibodies (Deng et al., 2014).”
PD-L1 (B7-H1) and PD-1 Pathway Blockade for Cancer Therapy: Mechanisms, Response Biomarkers and Combinations (2016, background): “In line with this notion, radiation therapy combined with anti-PD therapy can synergistically promote antitumor immunity in several tumor-bearing mouse models (159, 163, 165, 166).”
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022, background): “Secondly, radiotherapy upregulated the expression of PD-L1 on tumor cells, which can be utilized by additional α-PD-1/ PD-L1 [74].”
Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment (2017, background): “Preclinical studies suggested that radiation may increase the recruitment of T cells in the tumor microenvironment (Deng et al., 2014; Zeng et al., 2013).”
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen (2014, background): “As previously demonstrated by our group (36) and others (33, 37), the combination of directed XRT and immune checkpoint blockade resulted in increased inhibition of tumor outgrowth (Fig.”
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11 (2019, background): “Radiation can target PD-L1–expressing cells and regulatory T cells (15).”
Immune Checkpoint Blockade in Cancer Therapy. (2015, background): “Preclinical studies also suggest the possibility that radiotherapy can enhance the efficacy of CTLA-4 and PD-1 blockade.(99,100) Although some clinical cases and retrospective series suggest that radiotherapy may have enhanced the efficacy of immune checkpoint blockade in patients and is generally b”