Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.
By A. Morelli, A. Larregina, W. Shufesky, Mara L. G. Sullivan, D. Stolz, G. Papworth, A. Zahorchak, A. Logar, Zhiliang Wang, Simon C Watkins and 2 more. Blood, 2004
1,054 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/72a1186ccba1c4caa47fecc93831db5c483cc772
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In Immunology
- C. Théry
- G. Raposo
- Marina Colombo
- Richard J. Simpson
- W. Stoorvogel
- Guillaume van Niel
- Cristina Gutiérrez-Vázquez
- U. Hanisch
In Molecular Biology
- C. Théry
- G. Raposo
- Richard J. Simpson
- Marina Colombo
- A. Llorente
- Suresh Mathivanan
- Guillaume van Niel
- María Yáñez-Mó
Citations in the corpus
- Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “For instance, we can cite a specific role of LFA-1 on DCs to capture ICAM-1-bearing DC-EVs (Segura et al. 2005), or a partial inhibition of DC-EV capture by DCs by antibodies blocking either LFA-1, ICAM-1, αv or β3 integrins, or CD9 or CD81 tetraspanins (Morelli et al. 2004).”
- Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. (2014, positive): “Possible mechanisms of exosome uptake by target cells include specific binding to surface receptors (34, 35), fusion to the plasma membrane (36), or internalization (37).”
- Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “Others have speculated that this could be a receptor-mediated process (33,115,116), which suggests that cells could take up extracellular vesicles selectively based on their surface receptor repertoires.”
- Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “Accordingly, it comes as no surprise that most of the antibodies that have been shown so far to interfere with EV binding and uptake by recipient cells are directed against tetraspanins (CD9, CD81, Tspan8, and CD151), integrins (CD11a, CD11b, CD11c, CD18, CD49c, CD49e, CD51, and CD61), or integrin c”
- Routes and mechanisms of extracellular vesicle uptake (2014, background): “Antibodies that mask the binding sites of CD11a or its ligand ICAM-1 can reduce dendritic cell uptake of EVs (30).”
- Biological properties of extracellular vesicles and their physiological functions (2015, background): “In DCs, internalization of EVswas shown to be an active process (inhibited by cytochalasin D, EDTA or low temperatures, among others) and involved the action of integrins (CD51, CD61, CD11a), CD54, PS and MFGE8 (96).”
- Exosomes and their roles in immune regulation and cancer. (2015, background): “[103] Morelli AE, Larregina AT, Shufesky WJ, Sullivan ML, Stolz DB, Papworth GD, et al.”
- Exosomes are released by cultured cortical neurones. (2006, positive): “Indeed, exosomes secreted by APCs contain major histocompatibility complex class II antigens (MHC-II) (Thery et al., 1999, 2002a,b) and can be transferred to other APCs.”
- Exosome-mediated delivery of siRNA in vitro and in vivo (2012, methodology): “In this protocol, we use mouse neuronal Be(2)M17 cells and luciferaseexpressing human osteosarcoma cells (LucU20S).”