Redox potential of GSH/GSSG couple: assay and biological significance.

By Dean P. Jones. Methods in Enzymology, 2002

795 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/72832d12167ed795c5e7de27f52019a94a3c58dd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Guoyao Wu
2. Elias K. Michaelis
3. D. Wink
4. M. Grisham
5. M. Tarpey
6. V. Lushchak
7. S. Baldelli
8. Dean P. Jones

In Molecular Biology

1. Elias K. Michaelis
2. M. Grisham
3. D. Wink
4. M. Tarpey
5. V. Lushchak
6. Guoyao Wu
7. S. Baldelli
8. Dean P. Jones

Citations in the corpus

• Redefining Oxidative Stress (2006, positive): “Thus, the re-sults directly show that plasma GSH redox is oxidized during oxidative stress in humans.”
• Glutathione metabolism and its implications for health. (2004, background): “Remarkably, the past decade witnessed the discovery of novel roles for GSH in signal transduction, gene expression, apoptosis, protein glutathionylation, and nitric oxide (NO) metabolism (2,4).”
• Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “In most cells and tissues, the estimated redox potential for the GSH/GSSG couple ranges from −260 mV to −150 mV (cited after [10]).”
• Radical-free biology of oxidative stress. (2008, methodology): “Because 1) human plasma is a homogeneous fluid with no subcellular compartments, 2) no significant noncovalent binding occurs with proteins, and 3) the same analytic procedures were used for simultaneous measurements of all of the chemical species involved; the results show that the major low molecu”
• Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, positive): “Glutathione is a major non-protein antioxidant in cells and the ratio of its reduced and oxidized form (GSH/GSSG) is an indicator of cellular redox status (Schafer and Buettner, 2001; Jones, 2002).”
• The changing faces of glutathione, a cellular protagonist. (2003, background): “…and Drug Discovery July 2014 | Volume 5 | Article 151 | 72 Ribas et al. Glutathione and mitochondria Figure 4; Krahenbuhl et al., 1995; Armstrong and Jones, 2002; Garcia-Ruiz et al., 2002; Fernandez-Checa and Kaplowitz, 2005; Lluis et al., 2005, 2007; Mari et al., 2006, 2008, 2009; Lu and…”
• Glutathione: new roles in redox signaling for an old antioxidant (2014, background): “The estimated in vivo redox potential for the GSH/GSSG couple ranges from−260 mV to –150 mV depending on the conditions (Jones, 2002).”
• Oxidative stress in bone remodeling: role of antioxidants. (2017, background): “Thus, the GSH/GSSG ratio is a simple and useful indicator of cellular redox state (8, 9).”
• Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. (2004, methodology): “GSH and GSSG may be determined biochemically or by HPLC according to the method described by Jones (60).”