Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

By George A. Calin, C. Dumitru, M. Shimizu, R. Bichi, S. Zupo, E. Noch, Hansjuerg Aldler, Michael J. Keating, K. Rai, L. Rassenti and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

3,972 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/726fa5af9a99f441cdddb2f86ffec6d6c968a6d5

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Citations in the corpus

MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, positive): “In most of these patients, miR-15-a and miR-16-1 were down-regulated or deleted [28].”
miR-21-mediated tumor growth (2007, positive): “For instance, about 65% of investigated patients suffering from B-cell chronic lymphocytic leukemia (CLL) have been reported to show a deletion located at chromosome 13q14 where the miR-15 and miR-16 genes are located and are under-represented in many B-CLL patients (Calin et al., 2002).”
MicroRNA functions in animal development and human disease (2005, positive): “Many microRNAs are de-regulated in primary human tumours (Calin et al., 2002; Calin et al., 2004a; He et al., 2005; Lu et al., 2005).”
Microarray-based, high-throughput gene expression profiling of microRNAs (2004, positive): “Dysregulation of miRNAs may contribute to human disease, including cance”
BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas (2005, positive): “Low levels of miR-15 and miR-16 were reported in the majority of CLL cases, either by downregulation or by hemizygous and homozygous deletions of a 30 kb region at 13q14 [4].”
Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells (2009, positive): “Others, including miR-15/16, miR-34 and the let-7 miRNAs, are deleted or downregulated in cancers and are reported to act as tumorsuppressor genes (Calin et al., 2002; Johnson et al., 2005; Mayr et al., 2007; Yu et al., 2007; He et al., 2007).”
Microarray analysis of microRNA expression in the developing mammalian brain (2004, positive): “The mouse microRNA miR-181 has been implicated in the modulation of hematopoietic differentiation, and other mammalian microRNAs have been suggested to play roles in cancer [22,23].”
MicroRNAs in Common Human Diseases (2012, positive): “in which they demonstrated a frequent deletion of miRNA genes miR15 and miR16 among 65% of B-cell chronic lymphocytic leukemia (B-CLL) patients [44].”