miR-21-mediated tumor growth

By Sipahi Ml, Shuomin Zhu, Hailong Wu, Zhaohui Lu, Fangting Wu, Yin-yuan Mo. Oncogene, 2007

1,634 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/115b66ad89061c4ec1b520b188943f09cefdd478

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Citations in the corpus

A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis (2009, neutral): “However, the contributions of miR-10b, miR-21, and miR-373/520c specifically to metastasis promotion are not easily discerned because of their mitogenic and/or antiapoptotic roles (Voorhoeve et al., 2006; Ma et al., 2007; Si et al., 2007).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “…TPM1 and PDCD4 Asangani et al. (2008); Chan et al. (2005); Frankel et al. (2007); Loffler et al. (2007); Meng et al. (2007a); Roldo et al. (2006); Si et al. (2007); Zhu et al. (2007) miR-29 Suggested to participate in maintaining proper DNA methylation Reduced levels in B-CLL and NSCLC, enforced…”
MicroRNAs in development and disease. (2011, background): “In addition to its pro-growth and -metastasis effects, miR-21 also indirectly induces upregulation of Bcl-2 and, thus, exerts an antiapoptotic function (560).”
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer (2008, background): “Not only has it been implicated in the promotion of tumor growth (Si et al., 2007), proliferation (Roldo et al.”
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype (2007, background): “Notably, one miRNA, miR155, is differentially expressed in ER- versus ER+ tumors (Figure 3), overexpressed in breast tumors compared to normal controls [77,78] and additionally other tumor types, suggesting that this miRNA may have diagnostic potential beyond breast cancer [54,91-93].”
Modulation of K-ras-dependent lung tumorigenesis by microRNA-21 (2010, neutral): “In breast cancer MCF-7 cells, miR-21 knockdown results in suppression of cell growth in vitro and tumor growth in xenografts (Si et al., 2007).”
Tenets of PTEN tumor suppression. (2008, background): “Importantly, miR-21 is one of the most frequently upregulated miRNAs in cancer and has been shown to promote proliferation in glioblastoma and to inhibit apoptosis in breast cancer cell lines (Chan et al., 2005; Si et al., 2007; Volinia et al., 2006).”
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. (2008, background): “Inhibition of miR-21 inhibits cell growth in vitro and inhibits tumor growth in xenograft mouse models through an indirect down-regulation of the antiapoptotic factor, B-cell lymphoma 2 (Bcl-2).(38) Studies in human cell lines have shown miR-21 can also target the tumor suppressor genes, phosphatase”