Macrophage migration inhibitory factor: a regulator of innate immunity

By Thierry Calandra, T. Roger. Nature reviews. Immunology, 2003

1,761 citations recorded by the source corpus.

For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/71b4dd9ed6985d12efc83e9865b60a07345c1904

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Citations in the corpus

MAPK phosphatases — regulating the immune response (2007, background): “Macrophage migration-inhibitory factor (MIF) is a potent pro-inflammatory cytokin”
Helminth parasites – masters of regulation (2004, background): “MIF was first discovered as a stimulatory cytokine for macrophages, in in vitro studies of delayed-type hypersensitivity (219, 220), but is now recognized as a multipotent activator of the immune system with a generally inflammatory character (221, 222).”
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “MIF also promotes the secretion of downstreamcytokines, such asTNF-α, IFN-γ, and IL-1, and it promotes the activation of T cells [80].”
The immunology of sepsis (2008, background): “Macrophage migration inhibitory factor (MIF), originally described in T cells, was shown to be produced by the anterior pituitary gland during endotoxaemia; increased levels are associated with sepsis severity and inhibition of MIF can protect from death in various models of endotoxininduced shock, ”
Inflammation and cancer: An ancient link with novel potentials (2007, background): “MIF plays a central role in the innate immune response.(64) The MIF polymorphism is associated with the severity of chronic inflammatory diseases.”
Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “MIF plays an important role in both innate and adaptive immunity (100).”
Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes (2018, background): “Mif and Fabp5 have both been linked to cell growth, motility, inflammation, and immunomodulation in macrophages and other cells (Calandra and Roger, 2003; Kannan-Thulasiraman et al., 2010; Liu et al., 2010).”
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses (Bacher et al., 1996; Calandra and Roger, 2003).”