Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

By Neil J. McKenna, B. W. O'Malley. Cell, 2002

944 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/718819ac9acee11a3e76a40cb5698e319878002e

Citations in the corpus

• Estrogen signaling multiple pathways to impact gene transcription. (2006, neutral): “In fact, ERs need to interact with co-regulatory proteins (coactivators or co-repressors) to form a platform upon which additional proteins are assembled [12, 13].”
• Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export (2005, neutral): “In the nucleus, steroid hormone receptors bind to hormone response element DNA and recruit the factors necessary for assembling preinitiation complexes (94).”
• Chromatin accessibility pre-determines glucocorticoid receptor binding patterns (2011, neutral): “1,2).”
• Overview of Nomenclature of Nuclear Receptors (2006, neutral): “The p160 family of proteins, cAMP response element-binding protein (CBP), and p300 are considered to be among the first recruited by activated NRs (Chen et al., 2000; Vo and Goodman, 2001; McKenna and O’Malley, 2002).”
• Dynamic Patterned Expression of Orphan Nuclear Receptor Genes RORα and RORβ in Developing Mouse Forebrain (2003, neutral): “Nuclear receptors have important roles in regulating gene transcription and various aspects of development [McKenna and O’Malley, 2002].”
• Nuclear receptors — a perspective from Drosophila (2005, neutral): “Extensive studies over the past two decades have provided a detailed understanding of the molecular mechanisms by which nuclear receptors convert a hormonal signal into a transcriptional respons”
• Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, neutral): “coregulatory protein complexes, instead of being silenced by corepressors (86, 87).”
• Induced ncRNAs Allosterically Modify RNA Binding Proteins in cis to Inhibit Transcription (2008, neutral): “S5b), while the N-terminus (1-211) interacted with CBP (Fig.”
• NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells (2013, neutral): “Acetylation of histones by these factors modifies chromatin structure and provides a more accessible promoter environment for recruitment of components of the general transcriptional machinery [22].”
• Modulation of oestrogen receptor signalling by association with the activated dioxin receptor (2003, neutral): “ERs, which are members of the nuclear receptor (NR) famil”
• Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis (2003, neutral): “Discussion In addition to the large repertoire of tissue-specific, DNA-binding transcription factors, a large, intricately regulated network of co-activator and co-repressor complexes combinatorially modulate transcription in a tissue- and promoter-specific fashio”
• A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. (2007, neutral): “In contrast to NR coregulatory factors identified by biochemical methods (McKenna and O’Malley, 2002; Perissi and Rosenfeld, 2005), we used a systems approach uniting diverse data types combining chromosome-scale ChIP-on-chip analysis and gene expression profiling to identify a network of AR-collabo”
• International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, neutral): “Often, the repressive effects depend on the recruitment of histone deacetylases, but sometimes direct contacts with the basal transcription machinery are also possible (Glass and Rosenfeld, 2000; McKenna and O’Malley, 2002; Hebbar and Archer, 2003).”
• Thyroid hormone receptors in brain development and function (2007, neutral): “TRs influence gene expression by interacting with regulatory sites in target genes, in a similar way to other members of the nuclear receptor superfamil”
• The aryl hydrocarbon receptor complex and the control of gene expression. (2008, neutral): “The classic model of NR activation by ligand suggests that ligand facilitates an exchange of NCoR/ SMRT/Sin3/HDAC corepressor complexes for coactivator complexes with ATP-dependent chromatin remodeling and histone acetyl-transferase activities.(197,198) It has been suggested that this happens only i”
• The RNA polymerase II core promoter: a key component in the regulation of gene expression. (2002, neutral): “By complex formulae that have yet to be solved, the expression of each of these thousands of genes is controlled by a wide variety of mechanisms (e.g., see Lefstin and Yamamoto 1998; Roeder 1998; Struhl 1999; Glass and Rosenfeld 2000; Lee and Young 2000; Lemon and Tjian 2000; Strahl and Allis 2000; ”