Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

By F. Ohtake, K. Takeyama, Takahiro Matsumoto, H. Kitagawa, Yasuji Yamamoto, K. Nohara, C. Tohyama, A. Krust, J. Mimura, P. Chambon and 3 more. Nature, 2003

816 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fb878659cfc32efd02bf6dea3c947fd68fc91574

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Toshio Tanaka
2. M. Narazaki
3. A. Gore
4. L. Giudice
5. M. Denison
6. C. Tyler
7. D. Kime
8. A. Soshilov

Citations in the corpus

• Long-Term Exposure to Environmental Concentrations of the Pharmaceutical Ethynylestradiol Causes Reproductive Failure in Fish (2004, background): “…that disruption of reproductive systems by endocrine-disrupting chemicals (EDCs) may be affecting the reproductive health of wildlife populations (Guillette and Gunderson 2001; Kime 1998; Tyler et al. 1998; Van Der Kraak 1998) and possibly, of humans (Colborn and Clement 1992; Ohtake et al. 2003).”
• Principles for modulation of the nuclear receptor superfamily (2004, background): “Such an analysis will also be crucial for understanding the physiological effects of endocrine disruptors (for example, molecules of natural or synthetic origin that can mimic natural ligands) that are present in increasing amounts in our environment, an important example of which is the effects of ”
• IL-6 in inflammation, immunity, and disease. (2014, background): “Within the nucleus, the Ahr/Arnt heterodimer then binds to the xenobiotic response element (XRE), which leads to various toxicological effects (Fujii-Kuriyama et al. 1994; Dragan and Schrenk 2000; Ohtake et al. 2003; Puga et al. 2005).”
• Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. (2011, background): “In this instance, TCDD- and AhR-dependent enhancement of proteosomal degradation of ERa and ERb has been reported and appears to result from direct AhR:ER protein-protein interactions that leads to polyubiquitination of ERs by a E3 ubiquitin ligase activity found associated with the AhR (Beischlag e”
• Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “Thus, endocrine disruptors act via nuclear receptors, nonnuclear steroid hormone receptors (e.g., membrane ERs), nonsteroid receptors (e.g., neurotransmitter receptors such as the serotonin receptor, dopamine receptor, norepinephrine receptor), orphan receptors [e.g., aryl hydrocarbon receptor (AhR)”
• The aryl hydrocarbon receptor complex and the control of gene expression. (2008, background): “More recently, a direct interaction between AhR and ER, or transrepression, was proposed.(229) However, this was confounded by the observation that 3-methylcholanthrene at relatively high concentrations (10 μM) could induce both EREdriven luciferase activity and BrdU incorporation in the glandular e”
• Etiology, symptomatology, and diagnosis of uterine myomas. (2007, background): “An epidemiologic study of African-American women did not find an increased risk of myomas among smokers, and postulated that a decrease in estrogen may be countered by cell proliferation stimulated by components of smoke such as dioxin (49, 50).”