The RNA polymerase II core promoter: a key component in the regulation of gene expression.
By J. Butler, J. T. Kadonaga. Genes & Development, 2002
699 citations recorded by the source corpus.
The development, growth, and survival of eukaryotic organisms require the proper regulation of tens of thousands of genes. By complex formulae that have yet to be solved, the expression of each of these thousands of genes is controlled by a wide variety of mechanisms (e.g., see Lefstin and Yamamoto 1998; Roeder 1998; Struhl 1999; Glass and Rosenfeld 2000; Lee and Young 2000; Lemon and Tjian 2000; Strahl and Allis 2000; Courey and Jia 2001; Smale 2001; White 2001; Zhang and Reinberg 2001; Emerson 2002; McKenna and O’Malley 2002; Narlikar et al. 2002; Orphanides and Reinberg 2002; West et al. 2002). In this review, we will focus on one of these regulatory components—the RNA polymerase II core promoter.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8c84aa723ae8dbfe12c0bdc7bf4b9ce76a898b7c
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Citations in the corpus
- The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation (2010, background): “There also seems to be close mechanistic coupling between enhancers and core promoters”
- Genome-wide analysis of mammalian promoter architecture and evolution (2006, background): “The transcription factor Sp1 has been found to recruit TATA-binding protein in the absence of TATA boxe”
- Computational analysis of core promoters in the Drosophila genome (2002, background): “Recent observations have emphasized the importance of the core promoter, a region of about 100 base-pairs (bp) flanking the transcription start site (TSS), in regulating transcription [3,4].”