Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency
By C. Picard, A. Puel, M. Bonnet, Cheng-Lung Ku, J. Bustamante, Kun Yang, C. Soudais, S. Dupuis, J. Feinberg, C. Fieschi and 20 more. Science, 2003
674 citations recorded by the source corpus.
Subfields: Cancer Research, Immunology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/710fc0908284075ccc945cfa4e72d2969adf0ba5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Shizuo Akira
- R. Medzhitov
- T. Mogensen
- Satoshi Uematsu
- O. Takeuchi
- E. Kopp
- David Baltimore
- M. Lenardo
In Immunology
- Shizuo Akira
- R. Medzhitov
- T. Mogensen
- O. Takeuchi
- Satoshi Uematsu
- Taro Kawai
- E. Kopp
- David Baltimore
In Public Health, Environmental and Occupational Health
Citations in the corpus
- Interleukin-1 (IL-1) Pathway (2010, background): “Similarly, humans with mutations in the IRAK4 gene have defects in IL1RI and Toll-like receptor (TLR) signaling (45).”
- 30 years of NF-κB: a blossoming of relevance to human pathobiology (2017, positive): “Other monogenic diseases associated with NF-κB pathways Immunodeficiency and dysregulation: Mutations in MYD88 (myeloid differentiation primary response 88) and IRAK4 (interleukin 1 receptor associated kinase 4) cause clinically indistinguishable phenotypes, characterized by life-threatening, recurr”
- Recognition of microbial infection by Toll-like receptors. (2003, background): “Update An interesting recent report describes three children with ongoing life-long pyogenic bacterial infections [51].”
- Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “The third primary immunodeficiency, involving IRAK4, is inherited as an autosomal recessive disorder (294).”
- Pathogen recognition and innate immunity. (2006, positive): “Stimulation with TLRs recruits a complex of MyD88, IRAK-4, IRAK-1, TRAF6, and IRF-7.”
- Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors (2010, positive): “To confirm the role of TLRs and specifically of TLR7 and TLR8 for cytokine production, we purified CD14dim and CD14+ CD16 monocytes from the peripheral blood of patients deficient in myeloid differentiation primary response gene 88 (MYD88) and in some cases in interleukin-1 receptor-associated kinas”